Dipeptidyl Peptidase 7 (DPH7) Antibody (FITC)
169€ (20 µg)
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935106861
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name
Dipeptidyl Peptidase 7 (DPH7) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx313821
Description
DPH7 Antibody (FITC) is a Rabbit Polyclonal against DPH7 conjugated to FITC.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Dipeptidyl Peptidase 7 (DPH7) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BTV6 |
| Gene ID | 92715 |
| OMIM | 613210 |
| Alias | RRT2,WDR85,C9orf112,WD repeat-containing protein 85,Diphthamide biosynthesis protein 7,Diphthine methyltransferase |
| Background | Antibody anti-DPH7 |
| Status | RUO |
Descripción
DPH7 functions as a regulatory factor that ensures the fidelity and efficiency of the diphthamide biosynthetic process. While not directly involved in enzymatic reactions, DPH7 aids in the recognition and stabilization of intermediates, particularly during the amidination step catalyzed by DPH6. Structural and functional analyses suggest that DPH7 interacts with eEF2 and other biosynthetic enzymes, maintaining the integrity of the diphthamide synthesis complex. Loss of DPH7 function disrupts the maturation of diphthamide, rendering cells resistant to diphtheria toxin and reducing overall protein synthesis efficiency. DPH7 is broadly expressed, with high levels in tissues with active protein translation and energy metabolism. Emerging studies propose additional roles for DPH7 in cellular stress responses and protein quality control pathways. Mutations in DPH7 are associated with subtle defects in cellular growth and homeostasis, underscoring its auxiliary but critical role in the biosynthesis of diphthamide.
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