Human Diphthamide biosynthesis protein 7 (DPH7) ELISA Kit
715€ (96 tests)
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name
Human Diphthamide biosynthesis protein 7 (DPH7) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx510896
tested applications
ELISA
Description
Human Diphthamide biosynthesis protein 7 (DPH7) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Diphthamide biosynthesis protein 7 (DPH7) concentrations in serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Diphthamide biosynthesis protein 7 (DPH7) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9BTV6 |
| Gene ID | 92715 |
| OMIM | 613210 |
| Alias | RRT2,WDR85,C9orf112,WD repeat-containing protein 85,Diphthamide biosynthesis protein 7,Diphthine methyltransferase |
| Background | Elisa kits for DPH7 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
DPH7 functions as a regulatory factor that ensures the fidelity and efficiency of the diphthamide biosynthetic process. While not directly involved in enzymatic reactions, DPH7 aids in the recognition and stabilization of intermediates, particularly during the amidination step catalyzed by DPH6. Structural and functional analyses suggest that DPH7 interacts with eEF2 and other biosynthetic enzymes, maintaining the integrity of the diphthamide synthesis complex. Loss of DPH7 function disrupts the maturation of diphthamide, rendering cells resistant to diphtheria toxin and reducing overall protein synthesis efficiency. DPH7 is broadly expressed, with high levels in tissues with active protein translation and energy metabolism. Emerging studies propose additional roles for DPH7 in cellular stress responses and protein quality control pathways. Mutations in DPH7 are associated with subtle defects in cellular growth and homeostasis, underscoring its auxiliary but critical role in the biosynthesis of diphthamide.
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