2-(3-Amino-3-Carboxypropyl)Histidine Synthase Subunit 1 (DPH1) Antibody
377€ (100 µg)
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Name
2-(3-Amino-3-Carboxypropyl)Histidine Synthase Subunit 1 (DPH1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx236045
Tested Applications
ELISA, WB, IHC, IF/ICC
Description
OVCA1 Antibody is a Rabbit Polyclonal against OVCA1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: 2-(3-Amino-3-Carboxypropyl)Histidine Synthase Subunit 1 (DPH1) Immunogen: DPH1 homolog(S. cerevisiae) |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200, IF/ICC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 40-60 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BZG8 |
| Gene ID | 1801 |
| OMIM | 603527 |
| Alias | DPH2L,OVCA1,DEDSSH,DPH2L1,Diphthamide biosynthesis protein 1,Diphtheria toxin resistance protein 1,Ovarian cancer-associated gene 1 protein |
| Background | Antibody anti-DPH1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
DPH1 is a key enzyme involved in the biosynthesis of diphthamide, a unique post-translational modification of histidine residue found exclusively on eukaryotic elongation factor 2 (eEF2). This modification is critical for cellular protein synthesis and is targeted by bacterial toxins such as diphtheria toxin and Pseudomonas exotoxin A. DPH1 functions as part of a complex multiprotein pathway that catalyzes the initial step of diphthamide synthesis, converting a specific histidine residue on eEF2 into an intermediate form. Genetic mutations or deletions in DPH1 have been implicated in various human diseases, including developmental disorders and cancer. DPH1's role extends beyond diphthamide biosynthesis, with studies suggesting its involvement in embryonic development, particularly neural tube closure, and hematopoiesis. Structurally, DPH1 contains conserved domains required for its catalytic activity and interactions with other diphthamide biosynthesis proteins like DPH2 and DPH3. Loss of DPH1 function impairs cellular sensitivity to diphtheria toxin, providing a functional assay for its activity. DPH1 is ubiquitously expressed, with the highest levels found in actively proliferating tissues. It also exhibits a conserved role in diphthamide synthesis across eukaryotes, underscoring its evolutionary significance.
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