Human DPH3 homolog (DPH3) ELISA Kit
715€ (96 tests)
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935106861
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name
Human DPH3 homolog (DPH3) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx510886
tested applications
ELISA
Description
Human DPH3 homolog (DPH3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human DPH3 homolog (DPH3) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | DPH3 homolog (DPH3) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q96FX2 |
| OMIM | 608959 |
| Alias | DESR1,DPH3A,KTI11,ZCSL2,DELGIP,DELGIP1,CSL-type zinc finger-containing protein 2,DelGEF-interacting protein 1 |
| Background | Elisa kits for DPH3 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
DPH3 plays a supporting but essential role in diphthamide biosynthesis by stabilizing the DPH1-DPH2 complex and facilitating the transfer of intermediate molecules during the catalytic process. It functions as a small zinc-binding protein and is thought to act as an electron donor, aiding the reductive chemistry required for diphthamide formation. DPH3 mutations or downregulation lead to resistance to diphtheria toxin and defects in translational elongation due to impaired diphthamide synthesis. Unlike DPH1 and DPH2, DPH3 has a broader cellular role, including involvement in redox homeostasis and regulation of oxidative stress responses. DPH3 is also implicated in protein-protein interactions within the diphthamide biosynthesis complex, ensuring the proper assembly and function of the enzymatic machinery. Expression studies show that DPH3 is widely distributed across eukaryotic tissues, particularly in metabolically active cells. Loss-of-function mutations in DPH3 are associated with reduced cellular fitness and increased vulnerability to environmental stressors, further emphasizing its auxiliary but indispensable role in diphthamide synthesis.
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