SH2B - SH2B adaptor protein | Elisa - Clia - Antibody - Protein

Family main features

Background

SH2B adaptor protein, also known as SH2B1, is a member of the SH2-domain-containing signaling proteins that play critical roles in intracellular signal transduction. SH2B1 is involved in a variety of cellular processes, including growth, metabolism, and neural function, by linking receptor tyrosine kinases (RTKs) to downstream signaling pathways. This protein is ubiquitously expressed in many tissues, with particularly high levels in the brain, liver, and adipose tissue. SH2B1 is integral to the signaling pathways of several key hormones and growth factors, such as insulin, leptin, and nerve growth factor (NGF).


Protein Structure

SH2B1 is characterized by several functional domains:

  • Pleckstrin Homology (PH) Domain: This domain binds phosphoinositides in the cell membrane, targeting SH2B1 to specific membrane locations and facilitating its role in signaling.
  • Src Homology 2 (SH2) Domain: The SH2 domain binds to phosphorylated tyrosine residues on RTKs or other signaling proteins, mediating interactions with various partners involved in signal transduction.
  • Proline-Rich Regions: These regions provide binding sites for SH3 domain-containing proteins, further propagating signaling cascades.
  • Multiple Phosphorylation Sites: These sites allow for regulation by kinases, modulating SH2B1 activity and its interactions with other proteins.


Classification and Subtypes

SH2B1 has several isoforms resulting from alternative splicing, each with distinct but overlapping functions:

  • SH2B1α: Predominantly expressed in the brain and involved in neural signaling.
  • SH2B1β: Widely expressed and plays a role in metabolic regulation.
  • SH2B1γ: Implicated in immune response and inflammation.
  • SH2B1δ: Least studied, but potentially involved in specific tissue functions.


Function and Biological Significance

SH2B1 is integral to several key cellular processes:

  • Insulin Signaling: SH2B1 enhances insulin signaling by binding to the insulin receptor and facilitating downstream signaling, thus playing a critical role in glucose homeostasis and metabolism.
  • Leptin Signaling: SH2B1 is involved in leptin signaling pathways, which regulate energy balance, appetite, and body weight. It enhances the sensitivity of cells to leptin, influencing energy expenditure and fat storage.
  • Neurotrophic Signaling: SH2B1 mediates the effects of neurotrophic factors such as NGF, which are crucial for the growth, survival, and differentiation of neurons.
  • Cell Growth and Proliferation: By interacting with various RTKs, SH2B1 influences cell proliferation and differentiation, contributing to tissue growth and repair.


Clinical Issues

Dysregulation or mutations in SH2B1 are associated with several diseases and disorders:

  • Obesity: Mutations in SH2B1 can lead to obesity and related metabolic disorders by disrupting leptin and insulin signaling pathways.
  • Type 2 Diabetes: Given its role in insulin signaling, defects in SH2B1 function can contribute to insulin resistance and the development of type 2 diabetes.
  • Neurodevelopmental Disorders: Abnormal SH2B1 function may affect neurotrophic signaling, potentially contributing to neurodevelopmental and psychiatric disorders.
  • Cancer: Alterations in SH2B1 expression or function can influence cell growth and proliferation, potentially contributing to the development and progression of certain cancers.


Summary

SH2B1 adaptor protein is a multifunctional signaling protein that plays a crucial role in various cellular processes, including growth, metabolism, and neural function. Structurally, SH2B1 contains a PH domain for membrane localization, an SH2 domain for binding phosphorylated tyrosine residues, proline-rich regions, and multiple phosphorylation sites. It enhances insulin and leptin signaling, influences neurotrophic factor signaling, and regulates cell growth and proliferation. Dysregulation or mutations in SH2B1 are associated with obesity, type 2 diabetes, neurodevelopmental disorders, and cancer, highlighting its importance in maintaining cellular and metabolic homeostasis. Understanding the function and mechanisms of SH2B1 provides insights into its role in health and disease, making it a potential therapeutic target for various disorders.

SH2B1 Recommended name:

SH2B adaptor protein 1 (SH2B1)

Aliases for SH2B1

SH2B1, PSM, SH2B, SH2B adaptor protein 1

SH2B2 Recommended name:

SH2B adaptor protein 2 (SH2B2)

Aliases for SH2B2

SH2B2, APS, SH2B adaptor protein 2

SH2B3 Recommended name:

SH2B adaptor protein 3 (SH2B3)

Aliases for SH2B3

SH2B3, IDDM20, LNK, SH2B adaptor protein 3

En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Primary Antibodies, ELISA Kits, Proteins and Peptides) relacionados con SH2B - SH2B adaptor protein

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Esta página contiene 24 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda

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immunoassays

providerCodereferencenamereactivitysample typeassay typetest rangesensitivitypricesize 1uniprot idstatus
AbbexaSH2B1abx383165Human SH2B Adaptor Protein 1 (SH2B1) ELISA KitHumanTissue homogenates, cell lysates and other biological fluids.0.312 ng/ml - 20 ng/ml71596 testsQ9NRF2RUO
AbbexaSH2B2abx545644Human SH2B adapter protein 2 (SH2B2) ELISA KitHumanTissue homogenates, cell lysates and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsO14492RUO
AbbexaSH2B3abx545647Human SH2B Adapter Protein 3 (SH2B3) ELISA KitHumanTissue homogenates, cell lysates and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml< 0.07 ng/ml71596 testsQ9UQQ2RUO
AbbexaSH2B1abx545642Mouse SH2B adapter protein 1 (SH2B1) ELISA KitMouseTissue homogenates, cell lysates and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsQ91ZM2RUO
AbbexaSH2B2abx545645Mouse SH2B adapter protein 2 (SH2B2) ELISA KitMouseTissue homogenates, cell lysates and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsQ9JID9RUO
AbbexaSH2B3abx545648Mouse SH2B Adapter Protein 3 (SH2B3) ELISA KitMouseTissue homogenates, cell lysates and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml< 0.07 ng/ml71596 testsO09039RUO
AbbexaSH2B1abx545643Rat SH2B Adaptor Protein 1 (SH2B1) ELISA KitRatTissue homogenates, cell lysates and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsQ62985RUO
AbbexaSH2B2abx545646Rat SH2B Adaptor Protein 2 (SH2B2) ELISA KitRatTissue homogenates, cell lysates and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsQ9Z200RUO
AbbexaSH2B3abx545649Rat SH2B Adapter Protein 3 (SH2B3) ELISA KitRatTissue homogenates, cell lysates and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml< 0.07 ng/ml71596 testsP50745RUO

Primary Antibodies

providerCodereferencenamereactivityclonalityhostimmunogen targetisotypeconjugationtested applicationspricesize 1uniprot idstatus
FineTestSH2B1FNab07818anti- SH2B1 antibodyhumanpolyclonalRabbitSH2B adaptor protein 1IgGUnconjugatedELISA, WB, IP, IHC, IF100µgQ9NRF2RUO
AbbexaSH2B1abx321761SH2B Adaptor Protein 1 (SH2B1) AntibodyHumanPolyclonalRabbitSH2B Adaptor Protein 1 (SH2B1)UnconjugatedELISA, WB, IHC25050 µlQ9NRF2RUO
AbbexaSH2B1abx028518SH2B Adaptor Protein 1 (SH2B1) AntibodyHumanPolyclonalRabbitSH2B Adaptor Protein 1 (SH2B1)UnconjugatedELISA, WB25080 µlQ9NRF2RUO
AbbexaSH2B1abx237818SH2B Adaptor Protein 1 (SH2B1) AntibodyHumanPolyclonalRabbitSH2B Adaptor Protein 1 (SH2B1)UnconjugatedELISA, WB, IHC, IF/ICC, IP350100 µgQ9NRF2RUO
AbbexaSH2B1abx320666SH2B Adaptor Protein 1 (SH2B1) AntibodyHumanPolyclonalRabbitSH2B Adaptor Protein 1 (SH2B1)UnconjugatedELISA, IHC25050 µlQ9NRF2RUO
AbbexaSH2B1abx004263SH2B Adaptor Protein 1 (SH2B1) AntibodyHumanPolyclonalRabbitSH2B Adaptor Protein 1 (SH2B1)UnconjugatedIHC, IF/ICC17520 µlQ9NRF2RUO
AbbexaSH2B2abx014882SH2B Adaptor Protein 2 (SH2B2) AntibodyHumanPolyclonalRabbitSH2B Adaptor Protein 2 (SH2B2)UnconjugatedELISA, WB43.7510 µgO14492RUO
AbbexaSH2B2abx327510SH2B Adaptor Protein 2 (SH2B2) AntibodyHumanPolyclonalRabbitSH2B Adaptor Protein 2 (SH2B2)UnconjugatedELISA, WB187.550 µgO14492RUO
AbbexaSH2B2abx242466SH2B Adaptor Protein 2 (SH2B2) AntibodyHumanPolyclonalRabbitSH2B Adaptor Protein 2 (SH2B2)UnconjugatedELISA, IHC25050 µlO14492RUO
AbbexaSH2B2abx242474SH2B Adaptor Protein 2 (SH2B2) AntibodyHumanPolyclonalRabbitSH2B Adaptor Protein 2 (SH2B2)UnconjugatedELISA, IHC25050 µlO14492RUO
AbbexaSH2B3abx102566Lymphocyte Adaptor Protein (Lnk) AntibodyHumanPolyclonalRabbitLymphocyte Adaptor Protein (Lnk)UnconjugatedWB, IHC, IF/ICC275100 µlRUO
AbbexaSH2B3abx430033SH2B Adapter Protein 3 (SH2B3) AntibodyHumanPolyclonalGoatSH2B Adapter Protein 3 (SH2B3)UnconjugatedP-ELISA, WB387.5200 µlRUO
AbbexaSH2B3abx129380Lymphocyte Adaptor Protein (Lnk) AntibodyMousePolyclonalRabbitLymphocyte Adaptor Protein (Lnk)UnconjugatedWB, IHC, IF/ICC275100 µlRUO

Proteins and Peptides

providerCodereferencenameoriginexpressionhostconjugationtested applicationspricesize 1uniprot idstatus
AbbexaSH2B3abx067840Human Lymphocyte Adaptor Protein (Lnk) ProteinHumanRecombinantE. coliUnconjugatedWB, SDS-PAGE237.510 µgQ9UQQ2RUO
AbbexaSH2B3abx165995Mouse Lymphocyte Adaptor Protein (Lnk) ProteinMouseRecombinantE. coliUnconjugatedWB, SDS-PAGE237.510 µgRUO

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