Human Lymphocyte Adaptor Protein (Lnk) Protein

Name: Human Lymphocyte Adaptor Protein (Lnk) Protein
Brand: Abbexa
SKU: abx067840
Price: 247 EUR
Availability: OnlineOnly

Este producto es parte de SH2B - SH2B adaptor protein

Pida mas información

935106861

info@markelab.com

Precio

247€ (10 µg)

Protein SH2B3

proveedor

Abbexa

reference

abx067840

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Lymphocyte Adaptor Protein (Lnk) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).

Background

SH2B3, also known as LNK, is an SH2 domain-containing adaptor protein that acts as a negative regulator of cytokine and growth factor receptor signaling. It interacts with signaling molecules downstream of receptors like JAK2, MPL, and KIT, modulating pathways such as JAK/STAT and PI3K/Akt to maintain signaling balance. SH2B3 is predominantly expressed in hematopoietic cells, where it regulates hematopoiesis, immune cell development, and inflammatory responses by suppressing excessive cytokine signaling. Mutations or loss of SH2B3 are associated with hematological disorders, including myeloproliferative neoplasms, leukemia, and autoimmune diseases, due to hyperactive cytokine signaling. SH2B3 also plays roles in cardiovascular diseases and metabolic regulation by controlling inflammatory signaling and cellular proliferation. Knockout studies show hyperproliferation of hematopoietic cells, increased inflammatory responses, and susceptibility to myeloproliferative disorders, emphasizing its role as a critical negative regulator of hematopoietic and immune cell signaling.

Características del producto

origin

Human

host

E. coli

immunogen target

Lymphocyte Adaptor Protein (Lnk)

host

E. coli

conjugation

Unconjugated

form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

tested applications

WB, SDS-PAGE

size 1

10 µg

size 2

50 µg

size 3

100 µg

size 4

200 µg

size 5

500 µg

observerd MW

Molecular Weight: Calculated MW: 28.9 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Thr335-Ser561 Tag: N-terminal His tag

expression

Recombinant

purity

> 95%

buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

or code

SH2B3

dry ice

availability

Shipped within 5-7 working days.

alias

SH2B3, IDDM20, LNK, SH2B adaptor protein 3

uniprot id

https://www.uniprot.org/uniprotkb/Q9UQQ2

note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.

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