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Rat SH2B Adaptor Protein 1 (SH2B1) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
687.5€ (96 tests)
Elisa Kits SH2B1
proveedor
Abbexareference
abx545643Tested Applications
ELISAreactivity
Ratstatus
RUOclonality
Descripción
Rat SH2B Adaptor Protein 1 (SH2B1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat SH2B adapter protein 1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
SH2B1 is an adaptor protein containing an SH2 domain and pleckstrin homology (PH) domain, functioning in signaling pathways downstream of receptor tyrosine kinases and cytokine receptors. It interacts with key signaling molecules such as Janus kinases (JAKs), insulin receptor, IGF-1 receptor, and leptin receptor, regulating pathways like JAK/STAT, PI3K/Akt, and MAPK. SH2B1 is critical for energy homeostasis, glucose metabolism, and leptin signaling, playing an essential role in regulating appetite, body weight, and insulin sensitivity. It is predominantly expressed in the brain, liver, and adipose tissues, where it controls metabolic processes and growth factor signaling. Mutations or dysregulation of SH2B1 are linked to obesity, insulin resistance, and type 2 diabetes due to impaired leptin and insulin signaling. Knockout studies in mice demonstrate obesity, glucose intolerance, and reduced energy expenditure, highlighting its importance in metabolic regulation and energy balance.
Características del producto
category
ELISA Kits
immunogen target
SH2B Adaptor Protein 1 (SH2B1)
reactivity
Rat
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
detection method
Colorimetric
sample type
Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
alias
SH2B1,PSM, SH2B, SH2B adaptor protein 1
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
SH2B1
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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