Rat SH2B Adaptor Protein 1 (SH2B1) ELISA Kit
715€ (96 tests)
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Name
Rat SH2B Adaptor Protein 1 (SH2B1) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx545643
Tested Applications
ELISA
Description
Rat SH2B Adaptor Protein 1 (SH2B1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat SH2B adapter protein 1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Immunogen Target | SH2B Adaptor Protein 1 (SH2B1) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q62985 |
| Alias | SH2B1,PSM, SH2B, SH2B adaptor protein 1 |
| Background | Elisa Kits for: SH2B1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Background
SH2B1 is an adaptor protein containing an SH2 domain and pleckstrin homology (PH) domain, functioning in signaling pathways downstream of receptor tyrosine kinases and cytokine receptors. It interacts with key signaling molecules such as Janus kinases (JAKs), insulin receptor, IGF-1 receptor, and leptin receptor, regulating pathways like JAK/STAT, PI3K/Akt, and MAPK. SH2B1 is critical for energy homeostasis, glucose metabolism, and leptin signaling, playing an essential role in regulating appetite, body weight, and insulin sensitivity. It is predominantly expressed in the brain, liver, and adipose tissues, where it controls metabolic processes and growth factor signaling. Mutations or dysregulation of SH2B1 are linked to obesity, insulin resistance, and type 2 diabetes due to impaired leptin and insulin signaling. Knockout studies in mice demonstrate obesity, glucose intolerance, and reduced energy expenditure, highlighting its importance in metabolic regulation and energy balance.
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