935106861
info@markelab.com
Precio
687.5€ (96 tests)
Mouse SH2B adapter protein 2 (SH2B2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse SH2B adapter protein 2 concentrations in tissue homogenates, cell lysates and other biological fluids.
SH2B2, also known as APS (adaptor protein containing PH and SH2 domains), is an adaptor protein that regulates signal transduction downstream of receptor tyrosine kinases, including insulin receptor and c-KIT. It binds phosphorylated receptors and recruits downstream effectors such as PI3K and SOCS proteins, modulating pathways involved in insulin signaling, glucose uptake, and cell proliferation. SH2B2 is highly expressed in insulin-sensitive tissues and hematopoietic cells, where it regulates glucose homeostasis, hematopoiesis, and mast cell activation. It is also involved in negative feedback regulation by recruiting SOCS proteins, which inhibit receptor signaling and prevent excessive activation. Dysregulation of SH2B2 is linked to metabolic disorders, insulin resistance, and hematopoietic abnormalities. Knockout studies reveal defects in glucose metabolism, impaired hematopoiesis, and altered mast cell responses, underscoring its role in fine-tuning receptor-mediated signaling pathways.
ELISA Kits
SH2B adapter protein 2 (SH2B2)
Mouse
0.156 ng/ml - 10 ng/ml
Quantitative
Colorimetric
Tissue homogenates,Cell lysates,Other biological fluids
96 tests
SH2B2, APS, SH2B adaptor protein 2
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
SH2B2
No
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
Rabbit polyclonal antibody against SH2B2 protein. Immunogen region is Internal.
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