SH2B Adaptor Protein 2 (SH2B2) Antibody

Background

SH2B2, also known as APS (adaptor protein containing PH and SH2 domains), is an adaptor protein that regulates signal transduction downstream of receptor tyrosine kinases, including insulin receptor and c-KIT. It binds phosphorylated receptors and recruits downstream effectors such as PI3K and SOCS proteins, modulating pathways involved in insulin signaling, glucose uptake, and cell proliferation. SH2B2 is highly expressed in insulin-sensitive tissues and hematopoietic cells, where it regulates glucose homeostasis, hematopoiesis, and mast cell activation. It is also involved in negative feedback regulation by recruiting SOCS proteins, which inhibit receptor signaling and prevent excessive activation. Dysregulation of SH2B2 is linked to metabolic disorders, insulin resistance, and hematopoietic abnormalities. Knockout studies reveal defects in glucose metabolism, impaired hematopoiesis, and altered mast cell responses, underscoring its role in fine-tuning receptor-mediated signaling pathways.