SH2B Adapter Protein 3 (SH2B3) Antibody
416€ (200 µl)
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935106861
info@markelab.com
name
SH2B Adapter Protein 3 (SH2B3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx430033
tested applications
P-ELISA, WB
Description
SH2B3 Antibody is a Goat Polyclonal antibody against SH2B3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | SH2B Adapter Protein 3 (SH2B3) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/64000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 10019 |
| NCBI Accession | NP_005466.1 |
| Alias | SH2B3, IDDM20, LNK, SH2B adaptor protein 3 |
| Background | Antibody anti-SH2B3 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
SH2B3, also known as LNK, is an SH2 domain-containing adaptor protein that acts as a negative regulator of cytokine and growth factor receptor signaling. It interacts with signaling molecules downstream of receptors like JAK2, MPL, and KIT, modulating pathways such as JAK/STAT and PI3K/Akt to maintain signaling balance. SH2B3 is predominantly expressed in hematopoietic cells, where it regulates hematopoiesis, immune cell development, and inflammatory responses by suppressing excessive cytokine signaling. Mutations or loss of SH2B3 are associated with hematological disorders, including myeloproliferative neoplasms, leukemia, and autoimmune diseases, due to hyperactive cytokine signaling. SH2B3 also plays roles in cardiovascular diseases and metabolic regulation by controlling inflammatory signaling and cellular proliferation. Knockout studies show hyperproliferation of hematopoietic cells, increased inflammatory responses, and susceptibility to myeloproliferative disorders, emphasizing its role as a critical negative regulator of hematopoietic and immune cell signaling.
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