Human SH2B Adaptor Protein 1 (SH2B1) ELISA Kit
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Description
Human SH2B Adaptor Protein 1 (SH2B1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human SH2B1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | SH2B Adaptor Protein 1 (SH2B1) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9NRF2 |
| Gene ID | 25970 |
| OMIM | 608937 |
| Alias | SH2B1,PSM, SH2B, SH2B adaptor protein 1 |
| Background | Elisa kits for SH2B1 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
SH2B1 is an adaptor protein containing an SH2 domain and pleckstrin homology (PH) domain, functioning in signaling pathways downstream of receptor tyrosine kinases and cytokine receptors. It interacts with key signaling molecules such as Janus kinases (JAKs), insulin receptor, IGF-1 receptor, and leptin receptor, regulating pathways like JAK/STAT, PI3K/Akt, and MAPK. SH2B1 is critical for energy homeostasis, glucose metabolism, and leptin signaling, playing an essential role in regulating appetite, body weight, and insulin sensitivity. It is predominantly expressed in the brain, liver, and adipose tissues, where it controls metabolic processes and growth factor signaling. Mutations or dysregulation of SH2B1 are linked to obesity, insulin resistance, and type 2 diabetes due to impaired leptin and insulin signaling. Knockout studies in mice demonstrate obesity, glucose intolerance, and reduced energy expenditure, highlighting its importance in metabolic regulation and energy balance.
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