Rat SH2B Adaptor Protein 2 (SH2B2) ELISA Kit
715€ (96 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Rat SH2B Adaptor Protein 2 (SH2B2) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx545646
tested applications
ELISA
Description
Rat SH2B Adaptor Protein 2 (SH2B2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat SH2B adapter protein 2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | SH2B Adaptor Protein 2 (SH2B2) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9Z200 |
| Alias | SH2B2, APS, SH2B adaptor protein 2 |
| Background | Elisa kits for SH2B2 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
SH2B2, also known as APS (adaptor protein containing PH and SH2 domains), is an adaptor protein that regulates signal transduction downstream of receptor tyrosine kinases, including insulin receptor and c-KIT. It binds phosphorylated receptors and recruits downstream effectors such as PI3K and SOCS proteins, modulating pathways involved in insulin signaling, glucose uptake, and cell proliferation. SH2B2 is highly expressed in insulin-sensitive tissues and hematopoietic cells, where it regulates glucose homeostasis, hematopoiesis, and mast cell activation. It is also involved in negative feedback regulation by recruiting SOCS proteins, which inhibit receptor signaling and prevent excessive activation. Dysregulation of SH2B2 is linked to metabolic disorders, insulin resistance, and hematopoietic abnormalities. Knockout studies reveal defects in glucose metabolism, impaired hematopoiesis, and altered mast cell responses, underscoring its role in fine-tuning receptor-mediated signaling pathways.
Related Products
SH2B Adaptor Protein 2 (SH2B2) Antibody
Rabbit polyclonal antibody against SH2B2 protein. Immunogen region is Internal.
Ver Producto
SH2B Adaptor Protein 2 (SH2B2) Antibody
SH2B2 Antibody is a Rabbit Polyclonal against SH2B2.
Ver ProductoSH2B Adaptor Protein 2 (SH2B2) Antibody
SH2B2 Antibody is a Rabbit Polyclonal against SH2B2.
Ver Producto