Mouse SH2B Adapter Protein 3 (SH2B3) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Mouse SH2B Adapter Protein 3 (SH2B3) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx545648
tested applications
ELISA
Description
Mouse SH2B Adapter Protein 3 (SH2B3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse SH2B Adapter Protein 3 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | SH2B Adapter Protein 3 (SH2B3) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.07 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | O09039 |
| Gene ID | 16923 |
| Alias | SH2B3, IDDM20, LNK, SH2B adaptor protein 3 |
| Background | Elisa kits for SH2B3 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
SH2B3, also known as LNK, is an SH2 domain-containing adaptor protein that acts as a negative regulator of cytokine and growth factor receptor signaling. It interacts with signaling molecules downstream of receptors like JAK2, MPL, and KIT, modulating pathways such as JAK/STAT and PI3K/Akt to maintain signaling balance. SH2B3 is predominantly expressed in hematopoietic cells, where it regulates hematopoiesis, immune cell development, and inflammatory responses by suppressing excessive cytokine signaling. Mutations or loss of SH2B3 are associated with hematological disorders, including myeloproliferative neoplasms, leukemia, and autoimmune diseases, due to hyperactive cytokine signaling. SH2B3 also plays roles in cardiovascular diseases and metabolic regulation by controlling inflammatory signaling and cellular proliferation. Knockout studies show hyperproliferation of hematopoietic cells, increased inflammatory responses, and susceptibility to myeloproliferative disorders, emphasizing its role as a critical negative regulator of hematopoietic and immune cell signaling.
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