Human SH2B adapter protein 2 (SH2B2) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for SH2B2
proveedor
Abbexareference
abx545644Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human SH2B adapter protein 2 (SH2B2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human SH2B adapter protein 2 (SH2B2) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
SH2B2, also known as APS (adaptor protein containing PH and SH2 domains), is an adaptor protein that regulates signal transduction downstream of receptor tyrosine kinases, including insulin receptor and c-KIT. It binds phosphorylated receptors and recruits downstream effectors such as PI3K and SOCS proteins, modulating pathways involved in insulin signaling, glucose uptake, and cell proliferation. SH2B2 is highly expressed in insulin-sensitive tissues and hematopoietic cells, where it regulates glucose homeostasis, hematopoiesis, and mast cell activation. It is also involved in negative feedback regulation by recruiting SOCS proteins, which inhibit receptor signaling and prevent excessive activation. Dysregulation of SH2B2 is linked to metabolic disorders, insulin resistance, and hematopoietic abnormalities. Knockout studies reveal defects in glucose metabolism, impaired hematopoiesis, and altered mast cell responses, underscoring its role in fine-tuning receptor-mediated signaling pathways.
Características del producto
category
ELISA Kits
immunogen target
SH2B adapter protein 2 (SH2B2)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
SH2B2, APS, SH2B adaptor protein 2
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
SH2B2
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
Quizá le pueda interesar
SH2B Adaptor Protein 2 (SH2B2) Antibody
proveedor
Abbexareference
abx014882Tested Applications
WBreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalRabbit polyclonal antibody against SH2B2 protein. Immunogen region is Internal.
52€ (10 µg)
Ver másSH2B Adaptor Protein 2 (SH2B2) Antibody
proveedor
Abbexareference
abx242466Tested Applications
ELISA, IHCreactivity
Human, Ratstatus
RUOclonality
PolyclonalSH2B2 Antibody is a Rabbit Polyclonal against SH2B2.
260€ (50 µl)
Ver másSH2B Adaptor Protein 2 (SH2B2) Antibody
proveedor
Abbexareference
abx242474Tested Applications
ELISA, IHCreactivity
Human, Ratstatus
RUOclonality
PolyclonalSH2B2 Antibody is a Rabbit Polyclonal against SH2B2.
260€ (50 µl)
Ver más