SH2B Adaptor Protein 1 (SH2B1) Antibody
377€ (100 µg)
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Name
SH2B Adaptor Protein 1 (SH2B1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx237818
Tested Applications
ELISA, WB, IHC, IF/ICC, IP
Description
SH2B1 Antibody is a Rabbit Polyclonal against SH2B1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: SH2B Adaptor Protein 1 (SH2B1) Immunogen: SH2B adaptor protein 1 |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/200 - 1/2000, IHC: 1/20 - 1/200, IF/ICC: 1/20 - 1/200, IP: 1/200 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC, IP |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NRF2 |
| Gene ID | 25970 |
| OMIM | 608937 |
| Alias | SH2B1,PSM, SH2B, SH2B adaptor protein 1 |
| Background | Antibody anti-SH2B1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
SH2B1 is an adaptor protein containing an SH2 domain and pleckstrin homology (PH) domain, functioning in signaling pathways downstream of receptor tyrosine kinases and cytokine receptors. It interacts with key signaling molecules such as Janus kinases (JAKs), insulin receptor, IGF-1 receptor, and leptin receptor, regulating pathways like JAK/STAT, PI3K/Akt, and MAPK. SH2B1 is critical for energy homeostasis, glucose metabolism, and leptin signaling, playing an essential role in regulating appetite, body weight, and insulin sensitivity. It is predominantly expressed in the brain, liver, and adipose tissues, where it controls metabolic processes and growth factor signaling. Mutations or dysregulation of SH2B1 are linked to obesity, insulin resistance, and type 2 diabetes due to impaired leptin and insulin signaling. Knockout studies in mice demonstrate obesity, glucose intolerance, and reduced energy expenditure, highlighting its importance in metabolic regulation and energy balance.
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