GABBR - Gamma-Aminobutyric Acid B Receptor | Elisa - Clia - Antibody - Protein

Family main features


Background:

Gamma-Aminobutyric Acid B Receptors (GABBRs) are a class of G protein-coupled receptors (GPCRs) that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system. GABBRs were first identified and characterized in the 1980s and 1990s through pharmacological and molecular studies. GABBRs mediate the effects of GABA, leading to inhibition of neurotransmitter release and neuronal excitability. GABBRs are primarily expressed in the central nervous system, particularly in regions involved in synaptic transmission and neuronal excitability, such as the cerebral cortex, hippocampus, basal ganglia, and cerebellum. GABBRs are activated by the neurotransmitter GABA, which binds to the GABBR1 subunit. Several synthetic ligands, including agonists and antagonists, have been developed to selectively modulate GABBR activity for therapeutic purposes.GABBRs play crucial roles in regulating synaptic transmission, neuronal excitability, and synaptic plasticity in the central nervous system. Dysregulation of GABBR signaling is implicated in various neurological and psychiatric disorders


Structural Features:

  • Transmembrane Protein: GABBRs are seven-transmembrane domain receptors, typical of GPCRs.
  • Topology: They consist of an extracellular N-terminus, seven transmembrane helices connected by intracellular and extracellular loops, and an intracellular C-terminus.
  • Heterodimerization: GABBRs typically function as heterodimers composed of GABBR1 (GBR1) and GABBR2 (GBR2) subunits.


Subtypes and Classification:

GABBRs are classified into two main subtypes: GABBR1 and GABBR2.

GABBR1 serves as the ligand-binding subunit, while GABBR2 is required for G protein coupling and signal transduction.


Physiological Functions:

  • Inhibition of Neurotransmitter Release: Activation of GABBRs inhibits the release of neurotransmitters such as glutamate, leading to neuronal inhibition and reduced excitability.
  • Synaptic Plasticity: GABBRs play roles in synaptic plasticity processes such as long-term potentiation (LTP) and long-term depression (LTD), which are fundamental for learning and memory.
  • Regulation of Neuronal Excitability: GABBR activation hyperpolarizes neurons, decreasing their excitability and preventing excessive neuronal firing.


Clinical Implications:

  • Neurological Disorders: Dysregulation of GABBR signaling has been implicated in various neurological disorders, including epilepsy, anxiety disorders, depression, schizophrenia, and neuropathic pain.
  • Epilepsy: GABBR agonists have been investigated as potential antiepileptic drugs, while GABBR antagonists may exacerbate seizure activity.
  • Psychiatric Disorders: GABBRs are potential targets for the development of novel treatments for anxiety, depression, and schizophrenia.



GABBR1 Recommended name:

Gamma-Aminobutyric Acid B Receptor 1 (GABBR1)

Aliases for GABBR1

GABBR1,GPRC3A,GABA-B receptor 1,GABABR1,gamma-aminobutyric acid (GABA) B receptor 1,gamma-aminobutyric acid (GABA) B receptor

GABBR2 Recommended name:

Gamma-Aminobutyric Acid B Receptor 2 (GABBR2)

Aliases for GABBR2

GABBR2,GABABR2,HG20 ,G protein-coupled receptor 51,GABA-B R2 receptor,GPR51 [27,38],GPRC3B,gamma-aminobutyric acid (GABA) B receptor

En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies) relacionados con GABBR - Gamma-Aminobutyric Acid B Receptor

Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.

Esta página contiene 47 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda

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immunoassays

providerCodereferencenamereactivitysample typeassay typetest rangesensitivitypricesize 1uniprot idstatus
AbbexaGABBR1abx519573Human Gamma-Aminobutyric Acid B Receptor 1 (GABBR1) ELISA KitHumanSerum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml< 0.06 ng/ml71596 testsRUO
AbbexaGABBR1abx595243GABA-B Receptor Cell ELISA KitHuman513.596 testsQ9UBS5RUO
AbbexaGABBR2abx384947Human Gamma-Aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) ELISA KitHumanTissue homogenates, cell lysates and other biological fluids.Sandwich0.313 ng/ml - 20 ng/ml< 0.188 ng/ml71596 testsO75899RUO
AbbexaGABBR1abx519574Mouse Gamma-Aminobutyric Acid B Receptor 1 (GABBR1) ELISA KitMouseTissue homogenates, cell lysates and other biological fluids.Sandwich0.312 ng/ml - 20 ng/ml71596 testsQ9WV18RUO
AbbexaGABBR2abx389382Mouse Gamma-Aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) ELISA KitMouseTissue homogenates, cell lysates and other biological fluids.Sandwich78 pg/ml - 5000 pg/ml< 46.9 pg/ml71596 testsQ80T41RUO
AbbexaGABBR1abx519575Rat Gamma-Aminobutyric Acid B Receptor 1 (GABBR1) ELISA KitRatTissue homogenates, cell lysates and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsQ9Z0U4RUO
AbbexaGABBR2abx391374Rat Gamma-Aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) ELISA KitRatTissue homogenates, cell lysates and other biological fluids.Sandwich78 pg/ml - 5000 pg/ml< 46.9 pg/ml71596 testsO88871RUO

Primary Antibodies

providerCodereferencenamereactivityclonalityhostimmunogen targetisotypeconjugationtested applicationspricesize 1uniprot idstatus
FineTestGABBR1FNab03279anti- GABBR1 antibodyhumanpolyclonalRabbitgamma-aminobutyric acid(GABA) B receptor, 1IgGUnconjugatedELISA, WB100µgQ9UBS5RUO
AbbexaGABBR1abx433655Gamma-Aminobutyric Acid B Receptor 1 (GABBR1) AntibodyHumanPolyclonalGoatGamma-Aminobutyric Acid B Receptor 1 (GABBR1)UnconjugatedP-ELISA, IHC387.5200 µlRUO
AbbexaGABBR1abx131056Gamma-Aminobutyric Acid B Receptor 1 (gABBR1) AntibodyHumanPolyclonalRabbitGamma-Aminobutyric Acid B Receptor 1 (gABBR1)UnconjugatedWB, IHC, IF/ICC275100 µlRUO
AbbexaGABBR1abx443533Gamma-Aminobutyric Acid Type B Receptor Subunit 1 (Gabbr1) Antibody (HRP)HumanMonoclonalMouseGamma-Aminobutyric Acid Type B Receptor Subunit 1 (Gabbr1)HRPWB, IF/ICC600100 µgQ9Z0U4RUO
AbbexaGABBR1abx125861Gamma-Aminobutyric Acid B Receptor 1 (GABBR1) AntibodyHumanPolyclonalRabbitGamma-Aminobutyric Acid B Receptor 1 (GABBR1)UnconjugatedWB, IF/ICC17520 µlQ9UBS5RUO
AbbexaGABBR1abx444376Gamma-Aminobutyric Acid Type B Receptor Subunit 1 (Gabbr1) Antibody (PE)HumanMonoclonalMouseGamma-Aminobutyric Acid Type B Receptor Subunit 1 (Gabbr1)PEWB, IF/ICC600100 µgQ9Z0U4RUO
AbbexaGABBR1abx444095Gamma-Aminobutyric Acid Type B Receptor Subunit 1 (Gabbr1) Antibody (PerCP)HumanMonoclonalMouseGamma-Aminobutyric Acid Type B Receptor Subunit 1 (Gabbr1)PerCPWB, IF/ICC612.5100 µgQ9Z0U4RUO
AbbexaGABBR1abx233279Gamma-Aminobutyric Acid B Receptor 1 (GABBR1) AntibodyHumanPolyclonalRabbitGamma-Aminobutyric Acid B Receptor 1 (GABBR1)UnconjugatedELISA, WB350100 µgQ9UBS5RUO
AbbexaGABBR1abx328162Gamma-Aminobutyric Acid B Receptor 1 (GABBR1) AntibodyHumanPolyclonalRabbitGamma-Aminobutyric Acid B Receptor 1 (GABBR1)UnconjugatedELISA, WB, IF/ICC187.550 µgQ9UBS5RUO
AbbexaGABBR1abx112669Gamma-Aminobutyric Acid B Receptor 1 (gABBR1) AntibodyHumanPolyclonalRabbitGamma-Aminobutyric Acid B Receptor 1 (gABBR1)UnconjugatedELISA, WB612.5100 µlQ9UBS5RUO
AbbexaGABBR1abx441006Gamma-Aminobutyric Acid Type B Receptor Subunit 1 (Gabbr1) Antibody (ATTO594)HumanMonoclonalMouseGamma-Aminobutyric Acid Type B Receptor Subunit 1 (Gabbr1)ATTO594WB, IF/ICC612.5100 µgQ9Z0U4RUO
AbbexaGABBR1abx442972Gamma-Aminobutyric Acid Type B Receptor Subunit 1 (Gabbr1) Antibody (Biotin)HumanMonoclonalMouseGamma-Aminobutyric Acid Type B Receptor Subunit 1 (Gabbr1)BiotinWB, IF/ICC600100 µgQ9Z0U4RUO
AbbexaGABBR1abx443252Gamma-Aminobutyric Acid Type B Receptor Subunit 1 (Gabbr1) Antibody (FITC)HumanMonoclonalMouseGamma-Aminobutyric Acid Type B Receptor Subunit 1 (Gabbr1)FITCWB, IF/ICC600100 µgQ9Z0U4RUO
AbbexaGABBR1abx013083Gamma-Aminobutyric Acid Type B Receptor Subunit 1 (GABBR1) AntibodyHumanPolyclonalRabbitGamma-Aminobutyric Acid Type B Receptor Subunit 1 (GABBR1)UnconjugatedWB, IHC43.7510 µgQ9UBS5RUO
AbbexaGABBR1abx119150Gamma-Aminobutyric Acid B Receptor 1 (GABBR1) AntibodyHumanPolyclonalRabbitGamma-Aminobutyric Acid B Receptor 1 (GABBR1)UnconjugatedWB, IF/ICC43.7510 µgQ9UBS5RUO
AbbexaGABBR1abx442692Gamma-Aminobutyric Acid Type B Receptor Subunit 1 (Gabbr1) Antibody (APC)HumanMonoclonalMouseGamma-Aminobutyric Acid Type B Receptor Subunit 1 (Gabbr1)APCWB, IF/ICC612.5100 µgQ9Z0U4RUO
AbbexaGABBR1abx440163Gamma-Aminobutyric Acid Type B Receptor Subunit 1 (Gabbr1) Antibody (ATTO390)HumanMonoclonalMouseGamma-Aminobutyric Acid Type B Receptor Subunit 1 (Gabbr1)ATTO390WB, IF/ICC612.5100 µgQ9Z0U4RUO
AbbexaGABBR1abx213852Gamma-Aminobutyric Acid B Receptor 1 (GABBR1) AntibodyHumanPolyclonalRabbitGamma-Aminobutyric Acid B Receptor 1 (GABBR1)UnconjugatedELISA, IHC25050 µlQ9UBS5RUO
AbbexaGABBR1abx445014Gamma-Aminobutyric Acid Type B Receptor Subunit 1 (Gabbr1) AntibodyHumanMonoclonalMouseGamma-Aminobutyric Acid Type B Receptor Subunit 1 (Gabbr1)UnconjugatedWB, IF/ICC550100 µgQ9Z0U4RUO
AbbexaGABBR1abx440444Gamma-Aminobutyric Acid Type B Receptor Subunit 1 (Gabbr1) Antibody (ATTO488)HumanMonoclonalMouseGamma-Aminobutyric Acid Type B Receptor Subunit 1 (Gabbr1)ATTO488WB, IF/ICC612.5100 µgQ9Z0U4RUO
AbbexaGABBR1abx329964Gamma-Aminobutyric Acid B Receptor 1 (GABBR1) AntibodyHumanPolyclonalRabbitGamma-Aminobutyric Acid B Receptor 1 (GABBR1)UnconjugatedELISA, WB, IHC187.550 µgQ9UBS5RUO
AbbexaGABBR2abx016107Gamma-Aminobutyric Acid Type B Receptor Subunit 2 (GABBR2) AntibodyHumanMonoclonalMouseGamma-Aminobutyric Acid Type B Receptor Subunit 2 (GABBR2)UnconjugatedELISA, IHC362.5100 µlO75899RUO
AbbexaGABBR2abx224047Gamma-Aminobutyric Acid Type B Receptor Subunit 2 (GABBR2) AntibodyHumanMonoclonalMouseGamma-Aminobutyric Acid Type B Receptor Subunit 2 (GABBR2)ELISA, IHC, IF/ICC362.5100 µlO75899RUO
AbbexaGABBR2abx146033Gamma-Aminobutyric Acid Type B Receptor Subunit 2 (GABBR2) AntibodyHumanPolyclonalRabbitGamma-Aminobutyric Acid Type B Receptor Subunit 2 (GABBR2)UnconjugatedELISA, WB337.5100 µgRUO
AbbexaGABBR2abx006828Gamma-Aminobutyric Acid Type B Receptor Subunit 2 (GABBR2) AntibodyHumanPolyclonalRabbitGamma-Aminobutyric Acid Type B Receptor Subunit 2 (GABBR2)UnconjugatedWB17520 µlO75899RUO
AbbexaGABBR2abx321718Gamma-Aminobutyric Acid Type B Receptor Subunit 2 (GABBR2) AntibodyHumanPolyclonalRabbitGamma-Aminobutyric Acid Type B Receptor Subunit 2 (GABBR2)UnconjugatedELISA237.550 µlO75899RUO
AbbexaGABBR2abx444094Gamma-Aminobutyric Acid Type B Receptor Subunit 2 (Gabbr2) Antibody (PerCP)HumanMonoclonalMouseGamma-Aminobutyric Acid Type B Receptor Subunit 2 (Gabbr2)PerCPWB, IHC, IF/ICC612.5100 µgO88871RUO
AbbexaGABBR2abx444375Gamma-Aminobutyric Acid Type B Receptor Subunit 2 (Gabbr2) Antibody (PE)HumanMonoclonalMouseGamma-Aminobutyric Acid Type B Receptor Subunit 2 (Gabbr2)PEWB, IHC, IF/ICC600100 µgO88871RUO
AbbexaGABBR2abx119040Gamma-Aminobutyric Acid Type B Receptor Subunit 2 (GABBR2) AntibodyHumanPolyclonalRabbitGamma-Aminobutyric Acid Type B Receptor Subunit 2 (GABBR2)UnconjugatedWB43.7510 µgO75899RUO
AbbexaGABBR2abx440443Gamma-Aminobutyric Acid Type B Receptor Subunit 2 (Gabbr2) Antibody (ATTO488)HumanMonoclonalMouseGamma-Aminobutyric Acid Type B Receptor Subunit 2 (Gabbr2)ATTO488WB, IHC, IF/ICC612.5100 µgO88871RUO
AbbexaGABBR2abx443251Gamma-Aminobutyric Acid Type B Receptor Subunit 2 (Gabbr2) Antibody (FITC)HumanMonoclonalMouseGamma-Aminobutyric Acid Type B Receptor Subunit 2 (Gabbr2)FITCWB, IHC, IF/ICC600100 µgO88871RUO
AbbexaGABBR2abx112670Gamma-Aminobutyric Acid Type B Receptor Subunit 2 (gABBR2) AntibodyHumanPolyclonalRabbitGamma-Aminobutyric Acid Type B Receptor Subunit 2 (gABBR2)UnconjugatedELISA, IHC612.5100 µlO75899RUO
AbbexaGABBR2abx327074Gamma-Aminobutyric Acid Type B Receptor Subunit 2 (GABBR2) AntibodyHumanPolyclonalRabbitGamma-Aminobutyric Acid Type B Receptor Subunit 2 (GABBR2)UnconjugatedELISA, WB187.550 µgO75899RUO
AbbexaGABBR2abx442971Gamma-Aminobutyric Acid Type B Receptor Subunit 2 (Gabbr2) Antibody (Biotin)HumanMonoclonalMouseGamma-Aminobutyric Acid Type B Receptor Subunit 2 (Gabbr2)BiotinWB, IHC, IF/ICC600100 µgO88871RUO
AbbexaGABBR2abx445013Gamma-Aminobutyric Acid Type B Receptor Subunit 2 (Gabbr2) AntibodyHumanMonoclonalMouseGamma-Aminobutyric Acid Type B Receptor Subunit 2 (Gabbr2)UnconjugatedWB, IHC, IF/ICC550100 µgO88871RUO
AbbexaGABBR2abx442691Gamma-Aminobutyric Acid Type B Receptor Subunit 2 (Gabbr2) Antibody (APC)HumanMonoclonalMouseGamma-Aminobutyric Acid Type B Receptor Subunit 2 (Gabbr2)APCWB, IHC, IF/ICC612.5100 µgO88871RUO
AbbexaGABBR2abx441005Gamma-Aminobutyric Acid Type B Receptor Subunit 2 (Gabbr2) Antibody (ATTO594)HumanMonoclonalMouseGamma-Aminobutyric Acid Type B Receptor Subunit 2 (Gabbr2)ATTO594WB, IHC, IF/ICC612.5100 µgO88871RUO
AbbexaGABBR2abx443532Gamma-Aminobutyric Acid Type B Receptor Subunit 2 (Gabbr2) Antibody (HRP)HumanMonoclonalMouseGamma-Aminobutyric Acid Type B Receptor Subunit 2 (Gabbr2)HRPWB, IHC, IF/ICC600100 µgO88871RUO
AbbexaGABBR2abx440162Gamma-Aminobutyric Acid Type B Receptor Subunit 2 (Gabbr2) Antibody (ATTO390)HumanMonoclonalMouseGamma-Aminobutyric Acid Type B Receptor Subunit 2 (Gabbr2)ATTO390WB, IHC, IF/ICC612.5100 µgO88871RUO

Proteins and Peptides

providerCodereferencenameoriginexpressionhostconjugationtested applicationspricesize 1uniprot idstatus
AbbexaGABBR1abx650242Human Gamma-Aminobutyric Acid B Receptor 1 (gABBR1) ProteinHumanRecombinantE. coliUnconjugatedWB, SDS-PAGE237.510 µgQ9UBS5RUO

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