Gamma-Aminobutyric Acid B Receptor 1 (GABBR1) Antibody

Product specifications

Primary Antibodies

Gamma-Aminobutyric Acid B Receptor 1 (GABBR1)

Rabbit

Human, Mouse, Rat

ELISA: 1 µg/ml, WB: 1/1000 - 1/2000, IF/ICC: 1/100 - 1/500. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

Purified by affinity chromatography.

20 µl

100 µl

2 × 100 µl

Liquid

ELISA, WB, IF/ICC

PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.

Shipped within 5-10 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

Q9UBS5

2550

NP_068703.1

GABBR1,GPRC3A,GABA-B receptor 1,GABABR1,gamma-aminobutyric acid (GABA) B receptor 1,gamma-aminobutyric acid (GABA) B receptor

Antibody anti-GABBR1

RUO

Concentration: > 0.2 mg/ml - 

Descripción

GABBR1 is a subunit of the metabotropic GABA-B receptor, a G protein-coupled receptor that mediates the inhibitory effects of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system. GABBR1 forms an obligate heterodimer with GABBR2 to function effectively, and it couples to Gi/o proteins, inhibiting adenylate cyclase activity and reducing intracellular cAMP levels. This inhibition leads to decreased neurotransmitter release, regulation of synaptic transmission, and neuronal excitability. GABBR1 is widely expressed in the brain, particularly in regions involved in cognition, pain perception, and behavior. Dysregulation of GABBR1 is associated with neurological and psychiatric disorders, including epilepsy, anxiety, depression, and addiction. GABA-B receptors, including GABBR1, are targets for drugs like baclofen, which is used to treat spasticity and certain substance abuse disorders. Beyond the CNS, GABBR1 plays roles in insulin secretion and gastrointestinal motility. Its essential function in inhibitory neurotransmission makes GABBR1 a key target for therapeutic development in neurological and metabolic disorders.

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