Gamma-Aminobutyric Acid Type B Receptor Subunit 2 (GABBR2) Antibody
383.5€ (100 µl)
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935106861
info@markelab.com
name
Gamma-Aminobutyric Acid Type B Receptor Subunit 2 (GABBR2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx224047
tested applications
ELISA, IHC, IF/ICC
Description
GABBR2 Antibody is a Mouse Monoclonal against GABBR2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Gamma-Aminobutyric Acid Type B Receptor Subunit 2 (GABBR2) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/10000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Purification | Purified from ascites by Protein G chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC, IF/ICC |
| Buffer | PBS, containing 0.05% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O75899 |
| Gene ID | 9568 |
| OMIM | 607340 |
| Alias | GABBR2,GABABR2,HG20 ,G protein-coupled receptor 51,GABA-B R2 receptor,GPR51 [27,38],GPRC3B,gamma-aminobutyric acid (GABA) B receptor |
| Background | Antibody anti-GABBR2 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
GABBR2 is the partner subunit of the GABA-B receptor, forming a functional heterodimer with GABBR1. While GABBR1 is responsible for ligand binding, GABBR2 facilitates G protein activation and downstream signaling. GABBR2 couples to Gi/o proteins, leading to the inhibition of adenylate cyclase, reduced cAMP levels, and the opening of potassium channels while inhibiting calcium channels. This signaling reduces neuronal excitability and neurotransmitter release, mediating the inhibitory effects of GABA in the central nervous system. GABBR2 is highly expressed in brain regions involved in motor control, pain, and cognition, where it regulates synaptic plasticity and long-term depression (LTD). Dysregulation of GABBR2 has been implicated in disorders such as epilepsy, schizophrenia, depression, and drug addiction. GABA-B receptor modulators targeting GABBR2 are being explored for their therapeutic potential in neurological diseases, pain management, and mood disorders. The functional partnership of GABBR1 and GABBR2 highlights their combined role in maintaining inhibitory signaling and synaptic homeostasis in the brain.
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