Gamma-Aminobutyric Acid Type B Receptor Subunit 1 (Gabbr1) Antibody (HRP)

Este producto es parte de GABBR - Gamma-Aminobutyric Acid B Receptor
Gamma-Aminobutyric Acid Type B Receptor Subunit 1 (Gabbr1) Antibody (HRP)

Pida mas información

935106861

info@markelab.com

Precio

624€ (100 µg)

Antibody anti-GABBR1

proveedor

Abbexa

reference

abx443533

Tested Applications

WB, IF/ICC

reactivity

Human, Mouse, Rat

status

RUO

clonality

Monoclonal

Descripción

GABA-B Receptor 1 Antibody is a Mouse Monoclonal against GABA B Receptor 1.


Background

GABBR1 is a subunit of the metabotropic GABA-B receptor, a G protein-coupled receptor that mediates the inhibitory effects of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system. GABBR1 forms an obligate heterodimer with GABBR2 to function effectively, and it couples to Gi/o proteins, inhibiting adenylate cyclase activity and reducing intracellular cAMP levels. This inhibition leads to decreased neurotransmitter release, regulation of synaptic transmission, and neuronal excitability. GABBR1 is widely expressed in the brain, particularly in regions involved in cognition, pain perception, and behavior. Dysregulation of GABBR1 is associated with neurological and psychiatric disorders, including epilepsy, anxiety, depression, and addiction. GABA-B receptors, including GABBR1, are targets for drugs like baclofen, which is used to treat spasticity and certain substance abuse disorders. Beyond the CNS, GABBR1 plays roles in insulin secretion and gastrointestinal motility. Its essential function in inhibitory neurotransmission makes GABBR1 a key target for therapeutic development in neurological and metabolic disorders.

Características del producto

category

Primary Antibodies


clonality

Monoclonal


reactivity

Human, Mouse, Rat


immunogen target

Gamma-Aminobutyric Acid Type B Receptor Subunit 1 (Gabbr1)


host

Mouse


isotype

IgG1


conjugation

HRP


tested applications

WB, IF/ICC


purification

Purified by Protein G.


recommended dilution

WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.


buffer

PBS, pH 7.4, 50% glycerol, 0.09% sodium azide.


size 1

100 µg


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

GABBR1


dry ice

No


availability

Shipped within 5-12 working days.


alias

GABBR1,GPRC3A,GABA-B receptor 1,GABABR1,gamma-aminobutyric acid (GABA) B receptor 1,gamma-aminobutyric acid (GABA) B receptor


NCBI accession

NP_112290.2


note

Concentration: 1 mg/ml -


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