Human Gamma-Aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) ELISA Kit

Este producto es parte de GABBR - Gamma-Aminobutyric Acid B Receptor
Human Gamma-Aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for GABBR2

proveedor

Abbexa

reference

abx384947

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human Gamma-Aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human GABBR2 concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

GABBR2 is the partner subunit of the GABA-B receptor, forming a functional heterodimer with GABBR1. While GABBR1 is responsible for ligand binding, GABBR2 facilitates G protein activation and downstream signaling. GABBR2 couples to Gi/o proteins, leading to the inhibition of adenylate cyclase, reduced cAMP levels, and the opening of potassium channels while inhibiting calcium channels. This signaling reduces neuronal excitability and neurotransmitter release, mediating the inhibitory effects of GABA in the central nervous system. GABBR2 is highly expressed in brain regions involved in motor control, pain, and cognition, where it regulates synaptic plasticity and long-term depression (LTD). Dysregulation of GABBR2 has been implicated in disorders such as epilepsy, schizophrenia, depression, and drug addiction. GABA-B receptor modulators targeting GABBR2 are being explored for their therapeutic potential in neurological diseases, pain management, and mood disorders. The functional partnership of GABBR1 and GABBR2 highlights their combined role in maintaining inhibitory signaling and synaptic homeostasis in the brain.

Características del producto

category

ELISA Kits


immunogen target

Gamma-Aminobutyric Acid (GABA) B Receptor, 2 (GABBR2)


reactivity

Human


test range

0.313 ng/ml - 20 ng/ml


sensitivity

< 0.188 ng/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

GABBR2,GABABR2,HG20 ,G protein-coupled receptor 51,GABA-B R2 receptor,GPR51 [27,38],GPRC3B,gamma-aminobutyric acid (GABA) B receptor


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

GABBR2


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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