Mouse Gamma-Aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Mouse Gamma-Aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx389382
tested applications
ELISA
Description
Mouse Gamma-Aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse GABBR2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Gamma-Aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 78 pg/ml - 5000 pg/ml |
| Sensitivity | < 46.9 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q80T41 |
| Gene ID | 242425 |
| Alias | GABBR2,GABABR2,HG20 ,G protein-coupled receptor 51,GABA-B R2 receptor,GPR51 [27,38],GPRC3B,gamma-aminobutyric acid (GABA) B receptor |
| Background | Elisa kits for GABBR2 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
GABBR2 is the partner subunit of the GABA-B receptor, forming a functional heterodimer with GABBR1. While GABBR1 is responsible for ligand binding, GABBR2 facilitates G protein activation and downstream signaling. GABBR2 couples to Gi/o proteins, leading to the inhibition of adenylate cyclase, reduced cAMP levels, and the opening of potassium channels while inhibiting calcium channels. This signaling reduces neuronal excitability and neurotransmitter release, mediating the inhibitory effects of GABA in the central nervous system. GABBR2 is highly expressed in brain regions involved in motor control, pain, and cognition, where it regulates synaptic plasticity and long-term depression (LTD). Dysregulation of GABBR2 has been implicated in disorders such as epilepsy, schizophrenia, depression, and drug addiction. GABA-B receptor modulators targeting GABBR2 are being explored for their therapeutic potential in neurological diseases, pain management, and mood disorders. The functional partnership of GABBR1 and GABBR2 highlights their combined role in maintaining inhibitory signaling and synaptic homeostasis in the brain.
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