Gamma-Aminobutyric Acid Type B Receptor Subunit 2 (Gabbr2) Antibody (ATTO390)
650€ (100 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Gamma-Aminobutyric Acid Type B Receptor Subunit 2 (Gabbr2) Antibody (ATTO390)
category
Primary Antibodies
provider
Abbexa
reference
abx440162
tested applications
WB, IHC, IF/ICC
Description
GABA-B Receptor 2 Antibody is a Mouse Monoclonal against GABA B Receptor 2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Gamma-Aminobutyric Acid Type B Receptor Subunit 2 (Gabbr2) |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | ATTO390 |
| Isotype | IgG1 |
| Purification | Purified by Protein G. |
| Size 1 | 100 µg |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.4, 50% glycerol, 0.09% sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O88871 |
| Gene ID | 83633 |
| NCBI Accession | NP_113990.1 |
| Alias | GABBR2,GABABR2,HG20 ,G protein-coupled receptor 51,GABA-B R2 receptor,GPR51 [27,38],GPRC3B,gamma-aminobutyric acid (GABA) B receptor |
| Background | Antibody anti-GABBR2 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
GABBR2 is the partner subunit of the GABA-B receptor, forming a functional heterodimer with GABBR1. While GABBR1 is responsible for ligand binding, GABBR2 facilitates G protein activation and downstream signaling. GABBR2 couples to Gi/o proteins, leading to the inhibition of adenylate cyclase, reduced cAMP levels, and the opening of potassium channels while inhibiting calcium channels. This signaling reduces neuronal excitability and neurotransmitter release, mediating the inhibitory effects of GABA in the central nervous system. GABBR2 is highly expressed in brain regions involved in motor control, pain, and cognition, where it regulates synaptic plasticity and long-term depression (LTD). Dysregulation of GABBR2 has been implicated in disorders such as epilepsy, schizophrenia, depression, and drug addiction. GABA-B receptor modulators targeting GABBR2 are being explored for their therapeutic potential in neurological diseases, pain management, and mood disorders. The functional partnership of GABBR1 and GABBR2 highlights their combined role in maintaining inhibitory signaling and synaptic homeostasis in the brain.
Related Products
Gamma-Aminobutyric Acid Type B Receptor Subunit 2 (GABBR2) Antibody
GABBR2 Antibody is a Rabbit Polyclonal Antibody against GABBR2.
Ver Producto
Gamma-Aminobutyric Acid Type B Receptor Subunit 2 (GABBR2) Antibody
GABBR2 Antibody is a Mouse Monoclonal against GABBR2.
Ver ProductoGamma-Aminobutyric Acid Type B Receptor Subunit 2 (gABBR2) Antibody
gABBR2 Antibody is a Rabbit Polyclonal antibody against gABBR2.
Ver Producto