Family main features
The Cadherin EGF LAG seven-pass G-type receptor (CELSR) is not classified as a G protein-coupled receptor (GPCR). Instead, CELSR receptors are a distinct class of cell adhesion molecules that belong to the cadherin superfamily. They play essential roles in cell-cell adhesion, tissue morphogenesis, and planar cell polarity (PCP) signaling.
CELSR receptors are characterized by multiple extracellular cadherin (Cad) repeats, EGF-like domains, Laminin G-like domains, and seven transmembrane segments. They are classified into three subtypes: CELSR1, CELSR2, and CELSR3.
CELSR receptors mediate calcium-dependent homophilic cell-cell adhesion through their extracellular cadherin repeats. They are involved in establishing and maintaining tissue integrity and organization during embryonic development and tissue homeostasis in adulthood.
CELSR receptors also play a crucial role in the PCP pathway, a signaling mechanism that coordinates cell polarity and tissue morphogenesis in epithelial tissues. Through interactions with other PCP proteins, CELSR receptors regulate cell orientation, migration, and tissue patterning.
In the nervous system, CELSR receptors contribute to axon guidance, dendrite arborization, and synapse formation during neuronal development. They are involved in establishing neural circuitry and synaptic connectivity in the developing brain.
Dysregulation of CELSR receptor signaling is associated with developmental defects, including neural tube defects, craniofacial abnormalities, and cardiovascular malformations. Mutations in CELSR genes have been linked to neural tube closure defects such as spina bifida and craniorachischisis.
Although CELSR receptors are not directly targeted for therapeutic intervention, understanding their roles in development and disease may provide insights into potential strategies for treating conditions associated with defects in tissue morphogenesis and PCP signaling.
Cadherin EGF LAG seven-pass G-type receptor 1 (CELSR1)
CELSR1,ADGRC1,ME2,FMI2,CDHF9,HFMI2,ADGRC1,LMPHM9
Cadherin EGF LAG seven-pass G-type receptor 2 (CELSR2)
CELSR2,ADGRC2,MEGF3,multiple epidermal growth factor-like domains 3,CDHF10,Flamingo1
Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3)
CELSR3,ADGRC3,MEGF2,multiple epidermal growth factor-like domains 2,CDHF11, EGFL1, FMI1, HFMI1,RESDA1
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (ELISA Kits, Primary Antibodies, Proteins and Peptides, CLIA Kits) relacionados con CELSR - Cadherin EGF LAG seven-pass G-type receptor
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 36 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | CELSR1 | abx506145 | Human Cadherin EGF LAG seven-pass G-type receptor 1 (CELSR1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9NYQ6 | RUO | ||
Abbexa | CELSR2 | abx495188 | Human Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) CLIA Kit | Human | Tissue homogenates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.064 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | CELSR2 | abx151030 | Human Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) ELISA Kit | Human | Tissue homogenates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.07 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | CELSR3 | abx506150 | Human Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9NYQ7 | RUO | ||
Abbexa | CELSR1 | abx506146 | Mouse Cadherin EGF LAG seven-pass G-type receptor 1 (CELSR1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | O35161 | RUO | ||
Abbexa | CELSR2 | abx506148 | Mouse Cadherin EGF LAG seven-pass G-type receptor 2 (CELSR2) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9R0M0 | RUO | ||
Abbexa | CELSR3 | abx506151 | Mouse Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q91ZI0 | RUO | ||
Abbexa | CELSR2 | abx155330 | Rat Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) ELISA Kit | Rat | Tissue homogenates,Other biological fluids | Sandwich | 0.78 ng/ml - 50 ng/ml | < 0.24 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | CELSR2 | abx495189 | Rat Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) CLIA Kit | Rat | Tissue homogenates and other biological fluids. | Sandwich | 0.781 ng/ml - 50 ng/ml | < 0.24 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | CELSR3 | abx506152 | Rat Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | O88278 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CELSR1 | abx348956 | Cadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1) Antibody (HRP) | Human | Polyclonal | Rabbit | Cadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1) | HRP | ELISA | 250 | 50 µl | Q9NYQ6 | RUO | |
Abbexa | CELSR1 | abx348958 | Cadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1) Antibody (Biotin) | Human | Polyclonal | Rabbit | Cadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1) | Biotin | ELISA | 250 | 50 µl | Q9NYQ6 | RUO | |
Abbexa | CELSR1 | abx348955 | Cadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1) Antibody | Human | Polyclonal | Rabbit | Cadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q9NYQ6 | RUO | |
Abbexa | CELSR1 | abx348957 | Cadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1) Antibody (FITC) | Human | Polyclonal | Rabbit | Cadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1) | FITC | 250 | 50 µl | Q9NYQ6 | RUO | ||
Abbexa | CELSR1 | abx326358 | Cadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1) Antibody | Human | Polyclonal | Rabbit | Cadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1) | Unconjugated | ELISA, IF/ICC | 187.5 | 50 µg | Q9NYQ6 | RUO | |
Abbexa | CELSR2 | abx171501 | Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) Antibody | Human | Monoclonal | Mouse | Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) | Unconjugated | WB, IHC, IF/ICC | 787.5 | 1 ml | RUO | ||
Abbexa | CELSR2 | abx019031 | Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) Antibody | Human | Polyclonal | Rabbit | Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) | Unconjugated | WB, IF/ICC | 300 | 100 µg | Q9HCU4 | RUO | |
Abbexa | CELSR2 | abx104425 | Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) Antibody | Human | Polyclonal | Rabbit | Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | Q9HCU4 | RUO | |
Abbexa | CELSR2 | abx214881 | Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) Antibody | Human | Polyclonal | Rabbit | Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q9HCU4 | RUO | |
Abbexa | CELSR2 | abx241634 | Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) Antibody | Human | Polyclonal | Rabbit | Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q9HCU4 | RUO | |
Abbexa | CELSR2 | abx326797 | Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) Antibody | Human | Polyclonal | Rabbit | Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) | Unconjugated | ELISA, IHC, IF/ICC | 187.5 | 50 µg | Q9HCU4 | RUO | |
Abbexa | CELSR3 | abx348544 | Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3) Antibody (HRP) | Human | Polyclonal | Rabbit | Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3) | HRP | ELISA | 250 | 50 µl | Q9NYQ7 | RUO | |
Abbexa | CELSR3 | abx129021 | Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3) Antibody | Human | Polyclonal | Rabbit | Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO | ||
Abbexa | CELSR3 | abx348546 | Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3) Antibody (Biotin) | Human | Polyclonal | Rabbit | Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3) | Biotin | ELISA | 250 | 50 µl | Q9NYQ7 | RUO | |
Abbexa | CELSR3 | abx348543 | Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3) Antibody | Human | Polyclonal | Rabbit | Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q9NYQ7 | RUO | |
Abbexa | CELSR3 | abx348545 | Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3) Antibody (FITC) | Human | Polyclonal | Rabbit | Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3) | FITC | 250 | 50 µl | Q9NYQ7 | RUO | ||
Abbexa | CELSR3 | abx323144 | Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3) Antibody | Human | Polyclonal | Rabbit | Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3) | Unconjugated | ELISA, IHC, IF/ICC | 187.5 | 50 µg | Q9NYQ7 | RUO | |
Abbexa | CELSR3 | abx015220 | Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3) Antibody | Human | Polyclonal | Rabbit | Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3) | Unconjugated | ELISA, IF/ICC | 43.75 | 10 µg | Q9NYQ7 | RUO | |
Abbexa | CELSR3 | abx326373 | Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3) Antibody | Human | Polyclonal | Rabbit | Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3) | Unconjugated | ELISA, IF/ICC | 187.5 | 50 µg | Q9NYQ7 | RUO | |
Abbexa | CELSR2 | abx129487 | Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) Antibody | Mouse | Polyclonal | Rabbit | Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO | ||
Abbexa | CELSR3 | abx129594 | Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3) Antibody | Mouse | Polyclonal | Rabbit | Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CELSR2 | abx652724 | Rat Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 1800 | 1 mg | RUO | |
Abbexa | CELSR2 | abx065632 | Human Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | Q9HCU4 | RUO |
Abbexa | CELSR2 | abx167472 | Mouse Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | RUO | |
Abbexa | CELSR3 | abx166701 | Human Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | RUO | |
Abbexa | CELSR3 | abx168380 | Mouse Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | RUO |
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