Mouse Cadherin EGF LAG seven-pass G-type receptor 2 (CELSR2) ELISA Kit

Product specifications

ELISA Kits

Cadherin EGF LAG seven-pass G-type receptor 2 (CELSR2)

Mouse

Colorimetric

Quantitative

0.156 ng/ml - 10 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-15 working days. The validity for this kit is 6 months.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

Q9R0M0

53883

CELSR2,ADGRC2,MEGF3,multiple epidermal growth factor-like domains 3,CDHF10,Flamingo1

Elisa kits for CELSR2

RUO

Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

CELSR2 encodes Cadherin EGF LAG seven-pass G-type receptor 2, another member of the adhesion GPCR family that functions in the regulation of cell polarity and neuronal migration. CELSR2 is a key component of the Wnt/planar cell polarity (PCP) signaling pathway, coordinating neuronal guidance and proper axon outgrowth during brain development. CELSR2 is predominantly expressed in the developing brain, particularly in regions like the cerebral cortex, where it governs synapse formation and neuronal connectivity. Mutations in CELSR2 have been associated with neurodevelopmental disorders, including autism spectrum disorder (ASD) and intellectual disability, as disruptions in PCP signaling can impair brain structure and function. CELSR2 has also been identified in genome-wide studies as a gene linked to coronary artery disease (CAD) and lipid metabolism, particularly low-density lipoprotein cholesterol (LDL-C) regulation. Beyond its role in development, CELSR2 contributes to tissue regeneration and cancer progression, where it can influence epithelial-mesenchymal transition (EMT) and cell invasion. CELSR2's cadherin and EGF-like domains mediate both cell adhesion and intercellular signaling, making it critical for both normal development and disease states.

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