Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3) Antibody (HRP)

Este producto es parte de CELSR - Cadherin EGF LAG seven-pass G-type receptor
Product Graph
260€ (50 µl)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3) Antibody (HRP)
category
Primary Antibodies
provider
Abbexa
reference
abx348544
tested applications
ELISA

Description

Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3) Antibody (HRP) is a Rabbit Polyclonal antibody conjugated to HRP for the detection of Human CELSR3.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3)
Host
Rabbit
Reactivity
Human
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
HRP
Isotype
IgG
Purity
> 95%
Purification
Purified by Protein G chromatography.
Size 1
50 µl
Size 2
100 µl
Size 3
200 µl
Size 4
1 ml
Form
Liquid
Tested Applications
ELISA
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q9NYQ7
Gene ID
1951
Alias
CELSR3,ADGRC3,MEGF2,multiple epidermal growth factor-like domains 2,CDHF11, EGFL1, FMI1, HFMI1,RESDA1
Background
Antibody anti-CELSR3
Status
RUO

Descripción

CELSR3 encodes Cadherin EGF LAG seven-pass G-type receptor 3, a vital adhesion GPCR involved in the establishment of neuronal connectivity and axonal guidance. CELSR3 plays an essential role in the Wnt/planar cell polarity (PCP) pathway and regulates the development of neural circuits, particularly in the central nervous system. It is highly expressed in the developing brain and is crucial for processes such as neuronal migration, axon pathfinding, and dendrite orientation. CELSR3 is indispensable for the formation of major neural tracts like the thalamocortical and corticospinal pathways, which are necessary for sensory processing and motor control. Disruptions in CELSR3 lead to severe neurological disorders, including congenital brain malformations and epilepsy. Mutations in CELSR3 have also been linked to intellectual disabilities and schizophrenia, conditions that arise from impaired neuronal connectivity. Beyond its developmental role, CELSR3 has been implicated in glioblastoma and other cancers, where it promotes tumor cell invasion and loss of cell polarity. CELSR3's structure includes cadherin repeats and EGF-like domains that allow it to facilitate cell adhesion and signaling, highlighting its importance in both neurodevelopment and disease.

Related Products

abx015220

Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3) Antibody

Rabbit polyclonal antibody against CELSR3 protein. Immunogen region is C-terminal.

Ver Producto
abx129021

Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3) Antibody

Cadherin EGF LAG Seven Pass G-Type Receptor 3 Antibody is a Rabbit Polyclonal against Cadherin EGF LAG Seven Pass G-Type Receptor 3.

Ver Producto
abx129594

Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3) Antibody

Cadherin EGF LAG Seven Pass G-Type Receptor 3 Antibody is a Rabbit Polyclonal against Cadherin EGF LAG Seven Pass G-Type Receptor 3.

Ver Producto