Cadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1) Antibody

Este producto es parte de CELSR - Cadherin EGF LAG seven-pass G-type receptor
Cadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1) Antibody

Pida mas información

935106861

info@markelab.com

Precio

187.5€ (50 µg)

Antibody anti-CELSR1

proveedor

Abbexa

reference

abx326358

Tested Applications

ELISA, IF/ICC

reactivity

Human, Mouse, Rat

status

RUO

clonality

Polyclonal

Descripción

CELSR1 Antibody is a Rabbit Polyclonal against CELSR1.


Background

CELSR1 encodes the Cadherin EGF LAG seven-pass G-type receptor 1, a member of the adhesion GPCR (G-protein coupled receptor) family. CELSR1 is integral to the non-canonical Wnt/planar cell polarity (PCP) pathway, which regulates tissue polarity and cell orientation during development. It is expressed widely in developing tissues, particularly in the nervous system, skin, and vascular endothelium. CELSR1 plays a significant role in processes like neural tube closure, ensuring proper spinal cord formation. Mutations in CELSR1 are associated with neural tube defects such as spina bifida and craniorachischisis, conditions caused by the failure of the neural tube to close. In addition to its developmental role, CELSR1 is involved in angiogenesis, where it supports endothelial cell alignment during blood vessel formation. CELSR1's extracellular domains contain cadherin repeats, which mediate cell-cell adhesion, and EGF-like domains that influence cell signaling. Dysregulation of CELSR1 has been implicated in cancer metastasis, where it contributes to the loss of cell polarity and enhanced cell migration. CELSR1 is therefore of interest for its roles in embryonic development, wound healing, and disease pathogenesis, particularly in oncology and developmental biology.

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Human, Mouse, Rat


immunogen target

Cadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1)


host

Rabbit


conjugation

Unconjugated


form

Liquid


tested applications

ELISA, IF/ICC


purification

Purified by affinity chromatography.


buffer

PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.


size 1

50 µg


size 2

100 µg


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

CELSR1


dry ice

No


availability

Shipped within 5-10 working days.


alias

CELSR1,ADGRC1,ME2,FMI2,CDHF9,HFMI2,ADGRC1,LMPHM9


note

This product is for research use only.


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