Cadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1) Antibody

Este producto es parte de CELSR - Cadherin EGF LAG seven-pass G-type receptor
Product Graph
169€ (20 µl)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Cadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx348955
tested applications
ELISA, IHC

Description

Cadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1) Antibody is a Rabbit Polyclonal antibody for the detection of Human CELSR1.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Cadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1)
Host
Rabbit
Reactivity
Human
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by antigen affinity chromatography.
Size 1
20 µl
Size 2
50 µl
Size 3
100 µl
Size 4
200 µl
Size 5
1 ml
Form
Liquid
Tested Applications
ELISA, IHC
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q9NYQ6
Gene ID
9620
Alias
CELSR1,ADGRC1,ME2,FMI2,CDHF9,HFMI2,ADGRC1,LMPHM9
Background
Antibody anti-CELSR1
Status
RUO

Descripción

CELSR1 encodes the Cadherin EGF LAG seven-pass G-type receptor 1, a member of the adhesion GPCR (G-protein coupled receptor) family. CELSR1 is integral to the non-canonical Wnt/planar cell polarity (PCP) pathway, which regulates tissue polarity and cell orientation during development. It is expressed widely in developing tissues, particularly in the nervous system, skin, and vascular endothelium. CELSR1 plays a significant role in processes like neural tube closure, ensuring proper spinal cord formation. Mutations in CELSR1 are associated with neural tube defects such as spina bifida and craniorachischisis, conditions caused by the failure of the neural tube to close. In addition to its developmental role, CELSR1 is involved in angiogenesis, where it supports endothelial cell alignment during blood vessel formation. CELSR1's extracellular domains contain cadherin repeats, which mediate cell-cell adhesion, and EGF-like domains that influence cell signaling. Dysregulation of CELSR1 has been implicated in cancer metastasis, where it contributes to the loss of cell polarity and enhanced cell migration. CELSR1 is therefore of interest for its roles in embryonic development, wound healing, and disease pathogenesis, particularly in oncology and developmental biology.
Related Products
abx326358
Cadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1) Antibody
CELSR1 Antibody is a Rabbit Polyclonal against CELSR1.
Ver Producto
abx348955
Cadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1) Antibody
Cadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1) Antibody is a Rabbit Polyclonal antibody for the detection of Human CELSR1.
Ver Producto
abx348956
Cadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1) Antibody (HRP)
Cadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1) Antibody (HRP) is a Rabbit Polyclonal antibody conjugated to HRP for the detection of Human CELSR1.
Ver Producto