Mouse Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3) Protein

234€ (10 µg)
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935106861
info@markelab.com
name
Mouse Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx168380
tested applications
WB, SDS-PAGE
Description
Cadherin EGF LAG Seven Pass G-Type Receptor 3 Protein is a recombinant Mouse protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Proteins and Peptides |
Immunogen Target | Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3) |
Host | E. coli |
Origin | Mouse |
Conjugation | Unconjugated |
Observed MW | Molecular Weight: Calculated MW: 29.6 kDa Observed MW (SDS-PAGE): 29 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Val942-Ser1175 Tag: N-terminal His tag |
Expression | Recombinant |
Purity | > 95% |
Size 1 | 10 µg |
Size 2 | 50 µg |
Size 3 | 100 µg |
Size 4 | 200 µg |
Size 5 | 500 µg |
Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
Tested Applications | WB, SDS-PAGE |
Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
Availability | Shipped within 5-7 working days. |
Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
Alias | CELSR3,ADGRC3,MEGF2,multiple epidermal growth factor-like domains 2,CDHF11, EGFL1, FMI1, HFMI1,RESDA1 |
Background | Protein CELSR3 |
Status | RUO |
Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
CELSR3 encodes Cadherin EGF LAG seven-pass G-type receptor 3, a vital adhesion GPCR involved in the establishment of neuronal connectivity and axonal guidance. CELSR3 plays an essential role in the Wnt/planar cell polarity (PCP) pathway and regulates the development of neural circuits, particularly in the central nervous system. It is highly expressed in the developing brain and is crucial for processes such as neuronal migration, axon pathfinding, and dendrite orientation. CELSR3 is indispensable for the formation of major neural tracts like the thalamocortical and corticospinal pathways, which are necessary for sensory processing and motor control. Disruptions in CELSR3 lead to severe neurological disorders, including congenital brain malformations and epilepsy. Mutations in CELSR3 have also been linked to intellectual disabilities and schizophrenia, conditions that arise from impaired neuronal connectivity. Beyond its developmental role, CELSR3 has been implicated in glioblastoma and other cancers, where it promotes tumor cell invasion and loss of cell polarity. CELSR3's structure includes cadherin repeats and EGF-like domains that allow it to facilitate cell adhesion and signaling, highlighting its importance in both neurodevelopment and disease.
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