Mouse Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3) Protein

Este producto es parte de CELSR - Cadherin EGF LAG seven-pass G-type receptor
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234€ (10 µg)

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935106861
info@markelab.com
name
Mouse Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx168380
tested applications
WB, SDS-PAGE

Description

Cadherin EGF LAG Seven Pass G-Type Receptor 3 Protein is a recombinant Mouse protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3)
Host
E. coli
Origin
Mouse
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 29.6 kDa  Observed MW (SDS-PAGE): 29 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Val942-Ser1175
Tag: N-terminal His tag
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
CELSR3,ADGRC3,MEGF2,multiple epidermal growth factor-like domains 2,CDHF11, EGFL1, FMI1, HFMI1,RESDA1
Background
Protein CELSR3
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

CELSR3 encodes Cadherin EGF LAG seven-pass G-type receptor 3, a vital adhesion GPCR involved in the establishment of neuronal connectivity and axonal guidance. CELSR3 plays an essential role in the Wnt/planar cell polarity (PCP) pathway and regulates the development of neural circuits, particularly in the central nervous system. It is highly expressed in the developing brain and is crucial for processes such as neuronal migration, axon pathfinding, and dendrite orientation. CELSR3 is indispensable for the formation of major neural tracts like the thalamocortical and corticospinal pathways, which are necessary for sensory processing and motor control. Disruptions in CELSR3 lead to severe neurological disorders, including congenital brain malformations and epilepsy. Mutations in CELSR3 have also been linked to intellectual disabilities and schizophrenia, conditions that arise from impaired neuronal connectivity. Beyond its developmental role, CELSR3 has been implicated in glioblastoma and other cancers, where it promotes tumor cell invasion and loss of cell polarity. CELSR3's structure includes cadherin repeats and EGF-like domains that allow it to facilitate cell adhesion and signaling, highlighting its importance in both neurodevelopment and disease.

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