Mouse Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3) Protein

Background

CELSR3 encodes Cadherin EGF LAG seven-pass G-type receptor 3, a vital adhesion GPCR involved in the establishment of neuronal connectivity and axonal guidance. CELSR3 plays an essential role in the Wnt/planar cell polarity (PCP) pathway and regulates the development of neural circuits, particularly in the central nervous system. It is highly expressed in the developing brain and is crucial for processes such as neuronal migration, axon pathfinding, and dendrite orientation. CELSR3 is indispensable for the formation of major neural tracts like the thalamocortical and corticospinal pathways, which are necessary for sensory processing and motor control. Disruptions in CELSR3 lead to severe neurological disorders, including congenital brain malformations and epilepsy. Mutations in CELSR3 have also been linked to intellectual disabilities and schizophrenia, conditions that arise from impaired neuronal connectivity. Beyond its developmental role, CELSR3 has been implicated in glioblastoma and other cancers, where it promotes tumor cell invasion and loss of cell polarity. CELSR3's structure includes cadherin repeats and EGF-like domains that allow it to facilitate cell adhesion and signaling, highlighting its importance in both neurodevelopment and disease.