Cadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1) Antibody (FITC)
260€ (50 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Cadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx348957
Description
Cadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1) Antibody (FITC) is a Rabbit Polyclonal antibody conjugated to FITC for the detection of Human CELSR1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Cadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purification | Purified by antigen affinity chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Size 3 | 200 µl |
| Size 4 | 1 ml |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NYQ6 |
| Gene ID | 9620 |
| Alias | CELSR1,ADGRC1,ME2,FMI2,CDHF9,HFMI2,ADGRC1,LMPHM9 |
| Background | Antibody anti-CELSR1 |
| Status | RUO |
Descripción
CELSR1 encodes the Cadherin EGF LAG seven-pass G-type receptor 1, a member of the adhesion GPCR (G-protein coupled receptor) family. CELSR1 is integral to the non-canonical Wnt/planar cell polarity (PCP) pathway, which regulates tissue polarity and cell orientation during development. It is expressed widely in developing tissues, particularly in the nervous system, skin, and vascular endothelium. CELSR1 plays a significant role in processes like neural tube closure, ensuring proper spinal cord formation. Mutations in CELSR1 are associated with neural tube defects such as spina bifida and craniorachischisis, conditions caused by the failure of the neural tube to close. In addition to its developmental role, CELSR1 is involved in angiogenesis, where it supports endothelial cell alignment during blood vessel formation. CELSR1's extracellular domains contain cadherin repeats, which mediate cell-cell adhesion, and EGF-like domains that influence cell signaling. Dysregulation of CELSR1 has been implicated in cancer metastasis, where it contributes to the loss of cell polarity and enhanced cell migration. CELSR1 is therefore of interest for its roles in embryonic development, wound healing, and disease pathogenesis, particularly in oncology and developmental biology.
Related Products
Cadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1) Antibody
CELSR1 Antibody is a Rabbit Polyclonal against CELSR1.
Ver ProductoCadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1) Antibody
Cadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1) Antibody is a Rabbit Polyclonal antibody for the detection of Human CELSR1.
Ver ProductoCadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1) Antibody (HRP)
Cadherin EGF LAG Seven-Pass G-Type Receptor 1 (CELSR1) Antibody (HRP) is a Rabbit Polyclonal antibody conjugated to HRP for the detection of Human CELSR1.
Ver Producto