Human Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) Protein

Product specifications

Proteins and Peptides

Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2)

E. coli

Human

Unconjugated

Molecular Weight: Calculated MW: 30.8 kDa

Concentration: Prior to lyophilization: 200 µg/ml

Sequence Fragment: Leu544-Ser796

Tag: N-terminal His tag

Recombinant

> 95%

10 µg

50 µg

100 µg

200 µg

500 µg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

Shipped within 5-7 working days.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

Q9HCU4

CELSR2,ADGRC2,MEGF3,multiple epidermal growth factor-like domains 3,CDHF10,Flamingo1

Protein CELSR2

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

CELSR2 encodes Cadherin EGF LAG seven-pass G-type receptor 2, another member of the adhesion GPCR family that functions in the regulation of cell polarity and neuronal migration. CELSR2 is a key component of the Wnt/planar cell polarity (PCP) signaling pathway, coordinating neuronal guidance and proper axon outgrowth during brain development. CELSR2 is predominantly expressed in the developing brain, particularly in regions like the cerebral cortex, where it governs synapse formation and neuronal connectivity. Mutations in CELSR2 have been associated with neurodevelopmental disorders, including autism spectrum disorder (ASD) and intellectual disability, as disruptions in PCP signaling can impair brain structure and function. CELSR2 has also been identified in genome-wide studies as a gene linked to coronary artery disease (CAD) and lipid metabolism, particularly low-density lipoprotein cholesterol (LDL-C) regulation. Beyond its role in development, CELSR2 contributes to tissue regeneration and cancer progression, where it can influence epithelial-mesenchymal transition (EMT) and cell invasion. CELSR2's cadherin and EGF-like domains mediate both cell adhesion and intercellular signaling, making it critical for both normal development and disease states.

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