Human Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) Protein

Este producto es parte de CELSR - Cadherin EGF LAG seven-pass G-type receptor
Product Graph
234€ (10 µg)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Human Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx065632
tested applications
WB, SDS-PAGE

Description

Recombinant Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2)
Host
E. coli
Origin
Human
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 30.8 kDa

Concentration: Prior to lyophilization: 200 µg/ml

Sequence Fragment: Leu544-Ser796

Tag: N-terminal His tag
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q9HCU4
Alias
CELSR2,ADGRC2,MEGF3,multiple epidermal growth factor-like domains 3,CDHF10,Flamingo1
Background
Protein CELSR2
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

CELSR2 encodes Cadherin EGF LAG seven-pass G-type receptor 2, another member of the adhesion GPCR family that functions in the regulation of cell polarity and neuronal migration. CELSR2 is a key component of the Wnt/planar cell polarity (PCP) signaling pathway, coordinating neuronal guidance and proper axon outgrowth during brain development. CELSR2 is predominantly expressed in the developing brain, particularly in regions like the cerebral cortex, where it governs synapse formation and neuronal connectivity. Mutations in CELSR2 have been associated with neurodevelopmental disorders, including autism spectrum disorder (ASD) and intellectual disability, as disruptions in PCP signaling can impair brain structure and function. CELSR2 has also been identified in genome-wide studies as a gene linked to coronary artery disease (CAD) and lipid metabolism, particularly low-density lipoprotein cholesterol (LDL-C) regulation. Beyond its role in development, CELSR2 contributes to tissue regeneration and cancer progression, where it can influence epithelial-mesenchymal transition (EMT) and cell invasion. CELSR2's cadherin and EGF-like domains mediate both cell adhesion and intercellular signaling, making it critical for both normal development and disease states.

Related Products

abx019031

Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) Antibody

CELSR2 Antibody is a Rabbit Polyclonal antibody against Human.

Ver Producto
abx065632

Human Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) Protein

Recombinant Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).

Ver Producto
abx104425

Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) Antibody

Polyclonal Antibody to Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2).

Ver Producto