Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3) Antibody

Este producto es parte de CELSR - Cadherin EGF LAG seven-pass G-type receptor
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52€ (10 µg)

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935106861
info@markelab.com
name
Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015220
tested applications
ELISA, IF/ICC

Description

Rabbit polyclonal antibody against CELSR3 protein. Immunogen region is C-terminal.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
IF/ICC: 1/100 - 1/500, ELISA: 1/40000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen.
Size 1
10 µg
Size 2
100 µg
Size 3
200 µg
Size 4
300 µg
Size 5
1 mg
Form
Liquid
Tested Applications
ELISA, IF/ICC
Buffer
PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q9NYQ7
Alias
CELSR3,ADGRC3,MEGF2,multiple epidermal growth factor-like domains 2,CDHF11, EGFL1, FMI1, HFMI1,RESDA1
Background
Antibody anti-CELSR3
Status
RUO
Note
Concentration: 1 mg/ml -

Descripción

CELSR3 encodes Cadherin EGF LAG seven-pass G-type receptor 3, a vital adhesion GPCR involved in the establishment of neuronal connectivity and axonal guidance. CELSR3 plays an essential role in the Wnt/planar cell polarity (PCP) pathway and regulates the development of neural circuits, particularly in the central nervous system. It is highly expressed in the developing brain and is crucial for processes such as neuronal migration, axon pathfinding, and dendrite orientation. CELSR3 is indispensable for the formation of major neural tracts like the thalamocortical and corticospinal pathways, which are necessary for sensory processing and motor control. Disruptions in CELSR3 lead to severe neurological disorders, including congenital brain malformations and epilepsy. Mutations in CELSR3 have also been linked to intellectual disabilities and schizophrenia, conditions that arise from impaired neuronal connectivity. Beyond its developmental role, CELSR3 has been implicated in glioblastoma and other cancers, where it promotes tumor cell invasion and loss of cell polarity. CELSR3's structure includes cadherin repeats and EGF-like domains that allow it to facilitate cell adhesion and signaling, highlighting its importance in both neurodevelopment and disease.

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