Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) Antibody

Este producto es parte de CELSR - Cadherin EGF LAG seven-pass G-type receptor
Product Graph
312€ (100 µg)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx019031
tested applications
WB, IF/ICC

Description

CELSR2 Antibody is a Rabbit Polyclonal antibody against Human.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2)
Host
Rabbit
Reactivity
Human
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Immunogen affinity purified.
Size 1
100 µg
Tested Applications
WB, IF/ICC
Buffer
TBS, pH 7.4, 0.5% BSA, 40% glycerol and 0.05% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q9HCU4
Gene ID
1952
OMIM
604265
Alias
CELSR2,ADGRC2,MEGF3,multiple epidermal growth factor-like domains 3,CDHF10,Flamingo1
Background
Antibody anti-CELSR2
Status
RUO

Descripción

CELSR2 encodes Cadherin EGF LAG seven-pass G-type receptor 2, another member of the adhesion GPCR family that functions in the regulation of cell polarity and neuronal migration. CELSR2 is a key component of the Wnt/planar cell polarity (PCP) signaling pathway, coordinating neuronal guidance and proper axon outgrowth during brain development. CELSR2 is predominantly expressed in the developing brain, particularly in regions like the cerebral cortex, where it governs synapse formation and neuronal connectivity. Mutations in CELSR2 have been associated with neurodevelopmental disorders, including autism spectrum disorder (ASD) and intellectual disability, as disruptions in PCP signaling can impair brain structure and function. CELSR2 has also been identified in genome-wide studies as a gene linked to coronary artery disease (CAD) and lipid metabolism, particularly low-density lipoprotein cholesterol (LDL-C) regulation. Beyond its role in development, CELSR2 contributes to tissue regeneration and cancer progression, where it can influence epithelial-mesenchymal transition (EMT) and cell invasion. CELSR2's cadherin and EGF-like domains mediate both cell adhesion and intercellular signaling, making it critical for both normal development and disease states.

Related Products

abx019031

Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) Antibody

CELSR2 Antibody is a Rabbit Polyclonal antibody against Human.

Ver Producto
abx065632

Human Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) Protein

Recombinant Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).

Ver Producto
abx104425

Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) Antibody

Polyclonal Antibody to Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2).

Ver Producto