Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) Antibody
312€ (100 µg)
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935106861
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name
Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx019031
tested applications
WB, IF/ICC
Description
CELSR2 Antibody is a Rabbit Polyclonal antibody against Human.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Immunogen affinity purified. |
| Size 1 | 100 µg |
| Tested Applications | WB, IF/ICC |
| Buffer | TBS, pH 7.4, 0.5% BSA, 40% glycerol and 0.05% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9HCU4 |
| Gene ID | 1952 |
| OMIM | 604265 |
| Alias | CELSR2,ADGRC2,MEGF3,multiple epidermal growth factor-like domains 3,CDHF10,Flamingo1 |
| Background | Antibody anti-CELSR2 |
| Status | RUO |
Descripción
CELSR2 encodes Cadherin EGF LAG seven-pass G-type receptor 2, another member of the adhesion GPCR family that functions in the regulation of cell polarity and neuronal migration. CELSR2 is a key component of the Wnt/planar cell polarity (PCP) signaling pathway, coordinating neuronal guidance and proper axon outgrowth during brain development. CELSR2 is predominantly expressed in the developing brain, particularly in regions like the cerebral cortex, where it governs synapse formation and neuronal connectivity. Mutations in CELSR2 have been associated with neurodevelopmental disorders, including autism spectrum disorder (ASD) and intellectual disability, as disruptions in PCP signaling can impair brain structure and function. CELSR2 has also been identified in genome-wide studies as a gene linked to coronary artery disease (CAD) and lipid metabolism, particularly low-density lipoprotein cholesterol (LDL-C) regulation. Beyond its role in development, CELSR2 contributes to tissue regeneration and cancer progression, where it can influence epithelial-mesenchymal transition (EMT) and cell invasion. CELSR2's cadherin and EGF-like domains mediate both cell adhesion and intercellular signaling, making it critical for both normal development and disease states.
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