Family main features
LRRC8 (Leucine-Rich Repeat Containing 8) proteins are critical components of the volume-regulated anion channel (VRAC), which plays a significant role in cellular volume regulation. These proteins are characterized by leucine-rich repeats (LRRs) that facilitate protein-protein interactions and are essential for various physiological processes. The VRAC is crucial for maintaining cellular homeostasis by mediating the transport of chloride ions and other osmolytes across the cell membrane in response to changes in cell volume. Dysregulation of VRAC function can lead to pathological conditions, including cancer, neurodegenerative diseases, and cardiovascular disorders.
The VRAC is a heteromeric channel complex formed by different LRRC8 subunits, primarily LRRC8A, which is obligatory for channel function, and other LRRC8B-E subunits that modulate the channel's properties. This channel responds to osmotic swelling of cells by allowing the efflux of chloride ions and organic osmolytes, thus contributing to the regulatory volume decrease (RVD) process. The ability of cells to regulate their volume is essential for their survival and proper function, particularly in tissues exposed to varying osmotic conditions.
The LRRC8 proteins share a common structural framework:
The LRRC8 family consists of five known subunits:
LRRC8 proteins and VRAC play several key roles:
Dysfunction or altered expression of LRRC8 proteins and VRAC has been implicated in several diseases:
LRRC8 proteins are integral components of the volume-regulated anion channel (VRAC), essential for cellular volume regulation and various physiological processes. The channel is a heteromeric complex formed by different LRRC8 subunits, with LRRC8A being indispensable for its function. VRAC mediates chloride ion and osmolyte transport in response to cell swelling, aiding in the regulatory volume decrease process. Dysregulation of VRAC function is associated with numerous diseases, including cancer, neurodegenerative disorders, and cardiovascular conditions, highlighting its importance in maintaining cellular homeostasis and health. Understanding the molecular mechanisms of LRRC8 proteins and VRAC can provide insights into therapeutic strategies for these diseases.
Volume-regulated anion channel subunit LRRC8A
Leucine-rich repeat-containing protein 8A,Swelling protein 1,LRRC8,SWELL1,
Volume-regulated anion channel subunit LRRC8B,
Leucine-rich repeat-containing protein 8B,Kiaa0231
Volume-regulated anion channel subunit LRRC8C
Leucine-rich repeat-containing protein 8C
Volume-regulated anion channel subunit LRRC8D
Leucine-rich repeat-containing protein 8D, LRRC5,
Volume-regulated anion channel subunit LRRC8E
Leucine-rich repeat-containing protein 8E
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Primary Antibodies, ELISA Kits) relacionados con LRRC8 - Volume-regulated anion channel
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 24 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | LRRC8A | abx531474 | Human Leucine-rich repeat-containing protein 8A (LRRC8A) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q8IWT6 | RUO | ||
Abbexa | LRRC8B | abx531477 | Human Leucine-rich repeat-containing protein 8B (LRRC8B) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q6P9F7 | RUO | ||
Abbexa | LRRC8C | abx388322 | Human Leucine Rich Repeat Containing Protein 8C (LRRC8C) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.094 ng/ml | 687.5 | 96 tests | Q8TDW0 | RUO |
Abbexa | LRRC8D | abx388323 | Human Leucine Rich Repeat Containing Protein 8D (LRRC8D) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.313 ng/ml - 20 ng/ml | < 0.188 ng/ml | 687.5 | 96 tests | Q7L1W4 | RUO |
Abbexa | LRRC8E | abx531486 | Human Leucine-rich repeat-containing protein 8E (LRRC8E) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q6NSJ5 | RUO | ||
Abbexa | LRRC8A | abx531475 | Mouse Leucine-rich repeat-containing protein 8A (LRRC8A) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q80WG5 | RUO | ||
Abbexa | LRRC8B | abx531478 | Mouse Leucine-rich repeat-containing protein 8B (LRRC8B) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q5DU41 | RUO | ||
Abbexa | LRRC8C | abx531481 | Mouse Leucine-rich repeat-containing protein 8C (LRRC8C) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q8R502 | RUO | ||
Abbexa | LRRC8D | abx531484 | Mouse Leucine-rich repeat-containing protein 8D (LRRC8D) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q8BGR2 | RUO | ||
Abbexa | LRRC8E | abx531487 | Mouse Leucine-rich repeat-containing protein 8E (LRRC8E) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q66JT1 | RUO | ||
Abbexa | LRRC8A | abx531476 | Rat Volume-Regulated Anion Channel Subunit LRRC8A (LRRC8A) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q4V8I7 | RUO | ||
Abbexa | LRRC8C | abx531482 | Rat Leucine Rich Repeat Containing Protein 8C (LRRC8C) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q498T9 | RUO | ||
Abbexa | LRRC8D | abx531485 | Rat Leucine Rich Repeat Containing Protein 8D (LRRC8D) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q5U308 | RUO | ||
Abbexa | LRRC8E | abx531488 | Rat Volume-Regulated Anion Channel Subunit LRRC8E (LRRC8E) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q3KRC6 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | LRRC8C | FNab04861 | anti- LRRC8C antibody | human | polyclonal | Rabbit | leucine rich repeat containing 8 family, member C | IgG | Unconjugated | ELISA, IF, IHC | 100µg | Q8TDW0 | RUO | |
FineTest | LRRC8D | FNab04862 | anti- LRRC8D antibody | human | polyclonal | Rabbit | leucine rich repeat containing 8 family, member D | IgG | Unconjugated | ELISA, WB | 100µg | Q7L1W4 | RUO | |
Abbexa | LRRC8A | abx036939 | Volume-Regulated Anion Channel Subunit LRRC8A (LRRC8A) Antibody | Human | Polyclonal | Rabbit | Volume-Regulated Anion Channel Subunit LRRC8A (LRRC8A) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | LRRC8A | abx031061 | Volume-Regulated Anion Channel Subunit LRRC8A (LRRC8A) Antibody | Human | Polyclonal | Rabbit | Volume-Regulated Anion Channel Subunit LRRC8A (LRRC8A) | Unconjugated | ELISA, WB | 281.25 | 80 µl | Q8IWT6 | RUO | |
Abbexa | LRRC8C | abx234861 | Leucine Rich Repeat Containing Protein 8C (LRRC8C) Antibody | Human | Polyclonal | Rabbit | Leucine Rich Repeat Containing Protein 8C (LRRC8C) | Unconjugated | ELISA, IHC, IF/ICC | 350 | 100 µg | Q8TDW0 | RUO | |
Abbexa | LRRC8C | abx113468 | Leucine Rich Repeat Containing Protein 8C (LRRC8C) Antibody | Human | Polyclonal | Rabbit | Leucine Rich Repeat Containing Protein 8C (LRRC8C) | Unconjugated | ELISA, WB, IF/ICC | 612.5 | 100 µl | Q8TDW0 | RUO | |
Abbexa | LRRC8D | abx113469 | Leucine Rich Repeat Containing Protein 8D (LRRC8D) Antibody | Human | Polyclonal | Rabbit | Leucine Rich Repeat Containing Protein 8D (LRRC8D) | Unconjugated | ELISA, WB | 612.5 | 100 µl | Q7L1W4 | RUO | |
Abbexa | LRRC8D | abx234862 | Leucine Rich Repeat Containing Protein 8D (LRRC8D) Antibody | Human | Polyclonal | Rabbit | Leucine Rich Repeat Containing Protein 8D (LRRC8D) | Unconjugated | ELISA, WB | 350 | 100 µg | Q7L1W4 | RUO | |
Abbexa | LRRC8E | abx302001 | Volume-Regulated Anion Channel Subunit LRRC8E (LRRC8E) Antibody | Human | Polyclonal | Rabbit | Volume-Regulated Anion Channel Subunit LRRC8E (LRRC8E) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | Q6NSJ5 | RUO | |
Abbexa | LRRC8E | abx036597 | Volume-Regulated Anion Channel Subunit LRRC8E (LRRC8E) Antibody | Human | Polyclonal | Rabbit | Volume-Regulated Anion Channel Subunit LRRC8E (LRRC8E) | Unconjugated | ELISA, WB | 337.5 | 100 µg | RUO |
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