Human Leucine-rich repeat-containing protein 8E (LRRC8E) ELISA Kit
715€ (96 tests)
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935106861
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name
Human Leucine-rich repeat-containing protein 8E (LRRC8E) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx531486
tested applications
ELISA
Description
Human Leucine-rich repeat-containing protein 8E (LRRC8E) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Leucine-rich repeat-containing protein 8E (LRRC8E) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Leucine-rich repeat-containing protein 8E (LRRC8E) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q6NSJ5 |
| OMIM | 612891 |
| Alias | Leucine-rich repeat-containing protein 8E |
| Background | Elisa kits for LRRC8E |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
LRRC8E is a subunit of the volume-regulated anion channel (VRAC), which forms heteromeric channels in combination with LRRC8A and other LRRC8 paralogs to regulate chloride and osmolyte efflux under osmotic stress. LRRC8E contributes to the fine-tuning of VRAC conductance, ion selectivity, and channel kinetics, ensuring cellular adaptation to hypotonic conditions and mechanical stress. It is expressed in various tissues, including immune cells, muscle, and neuronal tissues, where it regulates cell volume, apoptosis, and ionic homeostasis. LRRC8E plays a role in immune cell function, proliferation, and cellular responses to swelling-induced stress, participating in processes like immune signaling and apoptotic volume decrease. Dysregulation of LRRC8E disrupts VRAC activity, contributing to pathological conditions such as immune dysfunction, neurodegenerative diseases, and cancer, where impaired ion homeostasis affects cell survival and growth. Knockout studies reveal diminished swelling-induced chloride currents, reduced apoptotic responses, and impaired cell volume regulation, underscoring its essential role in osmoregulation and adaptive responses to environmental stress.
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