Human Leucine Rich Repeat Containing Protein 8C (LRRC8C) ELISA Kit
715€ (96 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human Leucine Rich Repeat Containing Protein 8C (LRRC8C) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx388322
tested applications
ELISA
Description
Human Leucine Rich Repeat Containing Protein 8C (LRRC8C) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human LRRC8C concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Leucine Rich Repeat Containing Protein 8C (LRRC8C) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.094 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q8TDW0 |
| Gene ID | 84230 |
| OMIM | 612889 |
| Alias | Leucine-rich repeat-containing protein 8C |
| Background | Elisa kits for LRRC8C |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
LRRC8C is a subunit of the volume-regulated anion channel (VRAC), where it assembles with LRRC8A and other LRRC8 paralogs to form functional heteromeric channels involved in chloride and osmolyte efflux under osmotic stress. LRRC8C modulates the biophysical properties of VRAC, such as ion selectivity and conductance, determining the channel's responsiveness to hypotonic swelling and cellular needs. It is expressed across multiple tissues, including epithelial cells, muscle, and immune cells, where it regulates cell volume, proliferation, and apoptosis. LRRC8C is critical for osmoregulation, immune responses, and apoptotic pathways, particularly during cellular swelling and mechanical stress. Dysregulation of LRRC8C disrupts ion homeostasis, leading to pathological conditions such as immune dysregulation, neurodegeneration, and tumor progression due to defective apoptosis and cell volume control. Knockout models exhibit impaired VRAC activity, altered chloride efflux, and reduced apoptosis under osmotic stress, underscoring its role in maintaining ionic balance, cell survival, and adaptive cellular responses.
Related Products
anti- LRRC8C antibody
Non-essential component of the volume-regulated anion channel(VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member(LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition.
Ver Producto
Leucine Rich Repeat Containing Protein 8C (LRRC8C) Antibody
Leucine Rich Repeat Containing 8 Family, Member C Antibody is a Rabbit Polyclonal antibody against Leucine Rich Repeat Containing 8 Family, Member C.
Ver ProductoLeucine Rich Repeat Containing Protein 8C (LRRC8C) Antibody
LRRC8C Antibody is a Rabbit Polyclonal against LRRC8C.
Ver Producto