Volume-Regulated Anion Channel Subunit LRRC8A (LRRC8A) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. This family member is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Volume-Regulated Anion Channel Subunit LRRC8A (LRRC8A) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8IWT6 |
| Alias | Leucine-rich repeat-containing protein 8A,Swelling protein 1,LRRC8,SWELL1 |
| Background | Antibody anti-LRRC8A |
| Status | RUO |
Descripción
LRRC8A is a core component of the volume-regulated anion channel (VRAC), a heteromeric channel responsible for regulating cell volume through the efflux of chloride ions and osmolytes under hypotonic stress. It contains leucine-rich repeats (LRRs) and transmembrane domains, which enable it to form complexes with other LRRC8 family members, such as LRRC8B-E, to assemble functional VRAC channels. LRRC8A serves as an essential subunit for channel formation, as it interacts with partner subunits to determine VRAC conductance, ion selectivity, and tissue-specific function. It plays critical roles in cell volume regulation, apoptosis, and osmotic homeostasis, particularly in response to swelling-induced mechanical stress. LRRC8A is widely expressed across tissues, including epithelial cells, immune cells, and neurons. Dysregulation of LRRC8A impairs volume regulation, contributing to pathological conditions such as neurodegenerative diseases, ischemia, and cancer progression due to defective apoptotic signaling and cellular homeostasis. Knockout studies reveal impaired VRAC activity, compromised cell survival under osmotic stress, and defects in apoptosis, highlighting its importance in maintaining cellular ion balance and volume regulation.
Related Products
Volume-Regulated Anion Channel Subunit LRRC8A (LRRC8A) Antibody
This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. This family member is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
Ver Producto
Volume-Regulated Anion Channel Subunit LRRC8A (LRRC8A) Antibody
Rabbit Polyclonal against the LRRC8A protein.
Ver Producto
Human Leucine-rich repeat-containing protein 8A (LRRC8A) ELISA Kit
Human Leucine-rich repeat-containing protein 8A (LRRC8A) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Leucine-rich repeat-containing protein 8A (LRRC8A) concentrations in tissue homogenates, cell lysates and other biological fluids.
Ver Producto