Human Leucine Rich Repeat Containing Protein 8D (LRRC8D) ELISA Kit
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Description
Human Leucine Rich Repeat Containing Protein 8D (LRRC8D) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human LRRC8D concentrations in tissue homogenates, cell lysates and other biological fluids.
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Product specifications
| Category | ELISA Kits |
| Immunogen Target | Leucine Rich Repeat Containing Protein 8D (LRRC8D) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.313 ng/ml - 20 ng/ml |
| Sensitivity | < 0.188 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q7L1W4 |
| Gene ID | 55144 |
| OMIM | 612890 |
| Alias | Leucine-rich repeat-containing protein 8D, LRRC5 |
| Background | Elisa kits for LRRC8D |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
LRRC8D is one of the five subunits of the volume-regulated anion channel (VRAC), which plays a crucial role in cellular osmoregulation and volume control. This channel complex enables the efflux of chloride ions and organic osmolytes in response to cell swelling, maintaining cellular integrity under osmotic stress. Structurally, LRRC8D contains leucine-rich repeats (LRRs) in its extracellular domain, which contribute to its ability to interact with other VRAC subunits, including LRRC8A, the essential core component. LRRC8D is known for its unique substrate specificity, particularly its ability to facilitate the transport of certain drugs, such as cisplatin, and organic molecules like taurine and amino acids. Dysregulation of LRRC8D function has been implicated in chemoresistance, highlighting its role in cancer therapeutics. Furthermore, LRRC8D is crucial in the regulation of extracellular signaling and apoptosis, particularly in cells experiencing stress-induced swelling. Its importance extends to physiological processes such as kidney function, where osmolyte regulation is critical, making it a target of interest in pharmacological studies aiming to modulate VRAC activity.
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