Human Leucine-rich repeat-containing protein 8B (LRRC8B) ELISA Kit

Product specifications

ELISA Kits

Leucine-rich repeat-containing protein 8B (LRRC8B)

Human

Colorimetric

Quantitative

0.156 ng/ml - 10 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-15 working days. The validity for this kit is 6 months.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

Q6P9F7

612888

Leucine-rich repeat-containing protein 8B,Kiaa0231

Elisa kits for LRRC8B

RUO

Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

LRRC8B is a subunit of the volume-regulated anion channel (VRAC) that partners with LRRC8A to form heteromeric channels regulating the efflux of chloride ions and osmolytes during cell swelling and osmotic stress. It contains leucine-rich repeats (LRRs) that facilitate protein-protein interactions, modulating VRAC properties such as ion permeability and channel kinetics. LRRC8B is expressed in a variety of tissues, including the brain, kidney, and immune cells, where it contributes to cellular osmoregulation, apoptosis, and volume homeostasis. It plays a role in the fine-tuning of VRAC activity, influencing chloride conductance and transport specificity depending on cellular and environmental conditions. Dysregulation of LRRC8B has been associated with impaired cell volume control, altered apoptotic responses, and cellular dysfunction under osmotic stress, contributing to diseases like inflammation, neurodegeneration, and cancer. Knockout studies reveal diminished VRAC activity, reduced swelling-induced ion efflux, and impaired cellular adaptation to hypotonic stress, highlighting its role in maintaining cellular volume and ionic balance.

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