Volume-Regulated Anion Channel Subunit LRRC8E (LRRC8E) Antibody
357.5€ (100 µg)
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935106861
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name
Volume-Regulated Anion Channel Subunit LRRC8E (LRRC8E) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx036597
tested applications
ELISA, WB
Description
Rabbit Polyclonal against the LRRC8E protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Volume-Regulated Anion Channel Subunit LRRC8E (LRRC8E) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | Leucine-rich repeat-containing protein 8E |
| Background | Antibody anti-LRRC8E |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
LRRC8E is a subunit of the volume-regulated anion channel (VRAC), which forms heteromeric channels in combination with LRRC8A and other LRRC8 paralogs to regulate chloride and osmolyte efflux under osmotic stress. LRRC8E contributes to the fine-tuning of VRAC conductance, ion selectivity, and channel kinetics, ensuring cellular adaptation to hypotonic conditions and mechanical stress. It is expressed in various tissues, including immune cells, muscle, and neuronal tissues, where it regulates cell volume, apoptosis, and ionic homeostasis. LRRC8E plays a role in immune cell function, proliferation, and cellular responses to swelling-induced stress, participating in processes like immune signaling and apoptotic volume decrease. Dysregulation of LRRC8E disrupts VRAC activity, contributing to pathological conditions such as immune dysfunction, neurodegenerative diseases, and cancer, where impaired ion homeostasis affects cell survival and growth. Knockout studies reveal diminished swelling-induced chloride currents, reduced apoptotic responses, and impaired cell volume regulation, underscoring its essential role in osmoregulation and adaptive responses to environmental stress.
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