Family main features
SHANK1 (SH3 and multiple ankyrin repeat domains 1) is a member of the SHANK family of proteins, which play a pivotal role in the organization of the postsynaptic density (PSD) in excitatory synapses. SHANK proteins are essential scaffolding proteins that help in the assembly of various receptors, ion channels, and signaling proteins at the synapse. SHANK1 is predominantly expressed in the brain and is crucial for synaptic structure and function. Disruptions in SHANK1 and other SHANK family members have been linked to various neuropsychiatric disorders, including autism spectrum disorders (ASD), schizophrenia, and intellectual disability.
The SHANK1 protein consists of several distinct domains that facilitate its role as a scaffolding protein:
SHANK1 is one of three SHANK family members, which also includes SHANK2 and SHANK3. These proteins share similar domain structures but differ in their expression patterns and specific functions in the brain. SHANK1 is primarily found in the central nervous system and is highly expressed in the cerebral cortex, hippocampus, and cerebellum.
SHANK1 serves as a critical scaffolding protein in the PSD of excitatory synapses. Its primary functions include:
Mutations and deletions in the SHANK1 gene have been associated with neuropsychiatric disorders, particularly autism spectrum disorders. Studies have shown that disruptions in SHANK1 function can lead to abnormalities in synaptic structure and function, contributing to the cognitive and behavioral deficits observed in these conditions. Moreover, alterations in SHANK1 expression have been linked to schizophrenia and intellectual disability, further highlighting its importance in normal brain function and development.
SHANK1 is a vital scaffolding protein in the postsynaptic density of excitatory synapses, playing a crucial role in synaptic organization, signal transduction, and synaptic plasticity. Its structure includes multiple domains that facilitate interactions with a variety of synaptic proteins, enabling it to maintain synaptic stability and function. Disruptions in SHANK1 are associated with several neuropsychiatric disorders, underscoring its significance in brain health and disease. Understanding the molecular mechanisms involving SHANK1 can provide insights into the pathophysiology of these disorders and potential therapeutic targets.
SH3 and multiple ankyrin repeat domains 1 (SHANK1)
SSTRIP,SPANK-1,synamon
SH3 and multiple ankyrin repeat domains 2 (SHANK2)
SHANK2, AUTS17, CORTBP1, CTTNBP1, ProSAP1, SHANK, SPANK-3, SH3 and multiple ankyrin repeat domains 2
SH3 and multiple ankyrin repeat domains 3 (SHANK3)
KIAA1650,PROSAP2,PSAP2,Proline-rich synapse-associated protein 2,ProSAP2,SPANK-2
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (ELISA Kits, Primary Antibodies) relacionados con SHANK - SH3 and multiple ankyrin repeat domains 1
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Esta página contiene 51 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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FineTest | SHANK3 | EH4462 | Human SHANK3(SH3 and multiple ankyrin repeat domains protein 3)ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | Q9BYB0 | RUO | ||
Abbexa | SHANK1 | abx383183 | Human SH3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | < 12.5 pg/ml | 687.5 | 96 tests | Q9Y566 | RUO |
Abbexa | SHANK2 | abx545699 | Human SH3 and multiple ankyrin repeat domains protein 2 (SHANK2) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9UPX8 | RUO | ||
Abbexa | SHANK2 | abx545705 | Human Putative uncharacterized protein SHANK2-AS3 (SHANK2-AS3) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.07 ng/ml | 687.5 | 96 tests | Q9BTD1 | RUO |
Abbexa | SHANK3 | abx545702 | Human SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.1 ng/ml | 687.5 | 96 tests | Q9BYB0 | RUO |
Abbexa | SHANK1 | abx545697 | Mouse SH3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | D3YZU1 | RUO | ||
Abbexa | SHANK2 | abx545700 | Mouse SH3 and multiple ankyrin repeat domains protein 2 (SHANK2) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q80Z38 | RUO | ||
Abbexa | SHANK3 | abx545703 | Mouse SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.625 ng/ml - 40 ng/ml | < 0.30 ng/ml | 687.5 | 96 tests | Q4ACU6 | RUO |
Abbexa | SHANK1 | abx545698 | Rat SH3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 65.5 pg/ml - 4000 pg/ml | < 26.5 pg/ml | 687.5 | 96 tests | Q9WV48 | RUO |
Abbexa | SHANK2 | abx545701 | Rat SH3 And Multiple Ankyrin Repeat Domains 2 (SHANK2) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9QX74 | RUO | ||
Abbexa | SHANK3 | abx545704 | Rat SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.07 ng/ml | 687.5 | 96 tests | Q9JLU4 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | SHANK1 | FNab07837 | anti- SHANK1 antibody | human | polyclonal | Rabbit | SH3 and multiple ankyrin repeat domains 1 | IgG | Unconjugated | ELISA, WB | 100µg | Q9Y566 | RUO | |
Abbexa | SHANK1 | abx440974 | SH3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) Antibody (ATTO594) | Human | Monoclonal | Mouse | SH3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) | ATTO594 | WB, IHC, AM | 612.5 | 100 µg | Q9WV48 | RUO | |
Abbexa | SHANK1 | abx440412 | SH3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) Antibody (ATTO488) | Human | Monoclonal | Mouse | SH3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) | ATTO488 | WB, IHC, AM | 612.5 | 100 µg | Q9WV48 | RUO | |
Abbexa | SHANK1 | abx444344 | SH3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) Antibody (PE) | Human | Monoclonal | Mouse | SH3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) | PE | WB, IHC, AM | 600 | 100 µg | Q9WV48 | RUO | |
Abbexa | SHANK1 | abx445069 | SHANK1 / SHANK3 Antibody | Human | Monoclonal | Mouse | SHANK1/SHANK3 | Unconjugated | WB, IHC, IF/ICC | 550 | 100 µg | Q9JLU4 | RUO | |
Abbexa | SHANK1 | abx115512 | Sh3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) Antibody | Human | Polyclonal | Rabbit | Sh3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) | Unconjugated | ELISA, WB | 612.5 | 100 µl | Q9Y566 | RUO | |
Abbexa | SHANK1 | abx214392 | SH3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) Antibody | Human | Polyclonal | Rabbit | SH3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) | Unconjugated | ELISA, WB | 250 | 50 µl | Q9Y566 | RUO | |
Abbexa | SHANK1 | abx237837 | SH3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) Antibody | Human | Polyclonal | Rabbit | SH3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) | Unconjugated | ELISA, WB | 350 | 100 µg | Q9Y566 | RUO | |
Abbexa | SHANK1 | abx444982 | SH3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) Antibody | Human | Monoclonal | Mouse | SH3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) | Unconjugated | WB, IHC, AM | 550 | 100 µg | Q9WV48 | RUO | |
Abbexa | SHANK1 | abx440131 | SH3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) Antibody (ATTO390) | Human | Monoclonal | Mouse | SH3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) | ATTO390 | WB, IHC, AM | 612.5 | 100 µg | Q9WV48 | RUO | |
Abbexa | SHANK1 | abx442660 | SH3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) Antibody (APC) | Human | Monoclonal | Mouse | SH3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) | APC | WB, IHC, AM | 612.5 | 100 µg | Q9WV48 | RUO | |
Abbexa | SHANK1 | abx443501 | SH3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) Antibody (HRP) | Human | Monoclonal | Mouse | SH3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) | HRP | WB, IHC, AM | 600 | 100 µg | Q9WV48 | RUO | |
Abbexa | SHANK1 | abx443220 | SH3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) Antibody (FITC) | Human | Monoclonal | Mouse | SH3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) | FITC | WB, IHC, AM | 600 | 100 µg | Q9WV48 | RUO | |
Abbexa | SHANK1 | abx444063 | SH3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) Antibody (PerCP) | Human | Monoclonal | Mouse | SH3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) | PerCP | WB, IHC, AM | 612.5 | 100 µg | Q9WV48 | RUO | |
Abbexa | SHANK1 | abx442940 | SH3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) Antibody (Biotin) | Human | Monoclonal | Mouse | SH3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) | Biotin | WB, IHC, AM | 600 | 100 µg | Q9WV48 | RUO | |
Abbexa | SHANK2 | abx337666 | SH3 And Multiple Ankyrin Repeat Domains 2 (SHANK2) Antibody (Biotin) | Human | Polyclonal | Rabbit | SH3 And Multiple Ankyrin Repeat Domains 2 (SHANK2) | Biotin | ELISA | 162.5 | 20 µg | Q9UPX8 | RUO | |
Abbexa | SHANK2 | abx334318 | SH3 And Multiple Ankyrin Repeat Domains 2 (SHANK2) Antibody | Human | Polyclonal | Rabbit | SH3 And Multiple Ankyrin Repeat Domains 2 (SHANK2) | Unconjugated | ELISA, IHC | 162.5 | 20 µg | Q9UPX8 | RUO | |
Abbexa | SHANK2 | abx337665 | SH3 And Multiple Ankyrin Repeat Domains 2 (SHANK2) Antibody (FITC) | Human | Polyclonal | Rabbit | SH3 And Multiple Ankyrin Repeat Domains 2 (SHANK2) | FITC | 162.5 | 20 µg | Q9UPX8 | RUO | ||
Abbexa | SHANK2 | abx337664 | SH3 And Multiple Ankyrin Repeat Domains 2 (SHANK2) Antibody (HRP) | Human | Polyclonal | Rabbit | SH3 And Multiple Ankyrin Repeat Domains 2 (SHANK2) | HRP | ELISA | 162.5 | 20 µg | Q9UPX8 | RUO | |
Abbexa | SHANK2 | abx323779 | SH3 And Multiple Ankyrin Repeat Domains 2 (SHANK2) Antibody | Human | Polyclonal | Rabbit | SH3 And Multiple Ankyrin Repeat Domains 2 (SHANK2) | Unconjugated | ELISA, WB | 187.5 | 50 µg | Q9UPX8 | RUO | |
Abbexa | SHANK3 | abx444431 | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) Antibody (PE) | Human | Monoclonal | Mouse | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) | PE | WB, IHC, IF/ICC | 600 | 100 µg | Q9JLU4 | RUO | |
Abbexa | SHANK3 | abx442947 | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) Antibody (Biotin) | Human | Monoclonal | Mouse | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) | Biotin | WB, IHC, IF/ICC, IP, AM | 600 | 100 µg | Q9JLU4 | RUO | |
Abbexa | SHANK3 | abx440499 | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) Antibody (ATTO488) | Human | Monoclonal | Mouse | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) | ATTO488 | WB, IHC, IF/ICC | 612.5 | 100 µg | Q9JLU4 | RUO | |
Abbexa | SHANK3 | abx443307 | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) Antibody (FITC) | Human | Monoclonal | Mouse | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) | FITC | WB, IHC, IF/ICC | 600 | 100 µg | Q9JLU4 | RUO | |
Abbexa | SHANK3 | abx440419 | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) Antibody (ATTO488) | Human | Monoclonal | Mouse | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) | ATTO488 | WB, IHC, IF/ICC, IP, AM | 612.5 | 100 µg | Q9JLU4 | RUO | |
Abbexa | SHANK3 | abx443227 | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) Antibody (FITC) | Human | Monoclonal | Mouse | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) | FITC | WB, IHC, IF/ICC, IP, AM | 600 | 100 µg | Q9JLU4 | RUO | |
Abbexa | SHANK3 | abx443508 | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) Antibody (HRP) | Human | Monoclonal | Mouse | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) | HRP | WB, IHC, IF/ICC, IP, AM | 600 | 100 µg | Q9JLU4 | RUO | |
Abbexa | SHANK3 | abx440218 | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) Antibody (ATTO390) | Human | Monoclonal | Mouse | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) | ATTO390 | WB, IHC, IF/ICC | 612.5 | 100 µg | Q9JLU4 | RUO | |
Abbexa | SHANK3 | abx442747 | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) Antibody (APC) | Human | Monoclonal | Mouse | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) | APC | WB, IHC, IF/ICC | 612.5 | 100 µg | Q9JLU4 | RUO | |
Abbexa | SHANK3 | abx441061 | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) Antibody (ATTO594) | Human | Monoclonal | Mouse | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) | ATTO594 | WB, IHC, IF/ICC | 612.5 | 100 µg | Q9JLU4 | RUO | |
Abbexa | SHANK3 | abx443027 | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) Antibody (Biotin) | Human | Monoclonal | Mouse | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) | Biotin | WB, IHC, IF/ICC | 600 | 100 µg | Q9JLU4 | RUO | |
Abbexa | SHANK3 | abx444070 | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) Antibody (PerCP) | Human | Monoclonal | Mouse | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) | PerCP | WB, IHC, IF/ICC, IP, AM | 612.5 | 100 µg | Q9JLU4 | RUO | |
Abbexa | SHANK3 | abx444150 | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) Antibody (PerCP) | Human | Monoclonal | Mouse | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) | PerCP | WB, IHC, IF/ICC | 612.5 | 100 µg | Q9JLU4 | RUO | |
Abbexa | SHANK3 | abx444351 | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) Antibody (PE) | Human | Monoclonal | Mouse | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) | PE | WB, IHC, IF/ICC, IP, AM | 600 | 100 µg | Q9JLU4 | RUO | |
Abbexa | SHANK3 | abx440138 | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) Antibody (ATTO390) | Human | Monoclonal | Mouse | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) | ATTO390 | WB, IHC, IF/ICC, IP, AM | 612.5 | 100 µg | Q9JLU4 | RUO | |
Abbexa | SHANK3 | abx442667 | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) Antibody (APC) | Human | Monoclonal | Mouse | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) | APC | WB, IHC, IF/ICC, IP, AM | 612.5 | 100 µg | Q9JLU4 | RUO | |
Abbexa | SHANK3 | abx443588 | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) Antibody (HRP) | Human | Monoclonal | Mouse | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) | HRP | WB, IHC, IF/ICC | 600 | 100 µg | Q9JLU4 | RUO | |
Abbexa | SHANK3 | abx444989 | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) Antibody | Human | Monoclonal | Mouse | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) | Unconjugated | WB, IHC, IF/ICC, IP, AM | 550 | 100 µg | Q9JLU4 | RUO | |
Abbexa | SHANK3 | abx440981 | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) Antibody (ATTO594) | Human | Monoclonal | Mouse | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) | ATTO594 | WB, IHC, IF/ICC, IP, AM | 612.5 | 100 µg | Q9JLU4 | RUO | |
Abbexa | SHANK2 | abx027014 | SH3 And Multiple Ankyrin Repeat Domains 2 (SHANK2) Antibody | Mouse | Polyclonal | Rabbit | SH3 And Multiple Ankyrin Repeat Domains 2 (SHANK2) | Unconjugated | ELISA, WB | 281.25 | 80 µl | Q9UPX8 | RUO |
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