SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) Antibody (Biotin)
637€ (100 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx443027
tested applications
WB, IHC, IF/ICC
Description
SHANK1/SHANK3 Antibody is a Mouse Monoclonal conjugated to Biotin against SHANK3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/1000, IF/ICC: 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Biotin |
| Isotype | IgG2a |
| Purification | Purified by Protein G. |
| Size 1 | 100 µg |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.4, 50% glycerol, 0.1% sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9JLU4 |
| Gene ID | 59312 |
| NCBI Accession | NP_067708.1 |
| Alias | KIAA1650,PROSAP2,PSAP2,Proline-rich synapse-associated protein 2,ProSAP2,SPANK-2 |
| Background | Antibody anti-SHANK3 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
SHANK3 is a critical postsynaptic scaffold protein that assembles and stabilizes signaling complexes at excitatory synapses by connecting neurotransmitter receptors, ion channels, and actin cytoskeleton regulators. It contains SH3, ankyrin repeats, SAM, and PDZ domains, allowing it to interact with NMDA receptors, AMPA receptors, and mGluRs, facilitating synaptic signaling and plasticity. SHANK3 is highly expressed in the brain, particularly in the striatum, cortex, and hippocampus, where it regulates synaptic development, transmission, and plasticity. Mutations or deletions of SHANK3 are strongly associated with Phelan-McDermid syndrome, autism spectrum disorders (ASD), and intellectual disability, characterized by impaired synaptic function, neural connectivity, and behavior. SHANK3-deficient models show severe synaptic defects, altered dendritic spine morphology, and abnormal behavior, underscoring its fundamental role in excitatory synapse maintenance, neuronal communication, and cognitive processes.
Related Products
Human SHANK3(SH3 and multiple ankyrin repeat domains protein 3)ELISA Kit
Ver Producto
SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) Antibody (ATTO390)
SHANK3 Antibody is a Mouse Monoclonal against SHANK3.
Ver Producto
SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) Antibody (ATTO390)
SHANK1/SHANK3 Antibody is a Mouse Monoclonal conjugated to ATTO 390 against SHANK3.
Ver Producto