Mouse SH3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for SHANK1
proveedor
Abbexareference
abx545697Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse SH3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse SH3 and multiple ankyrin repeat domains protein 1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
SHANK1 is a scaffold protein in the postsynaptic density (PSD) of excitatory synapses that links receptors, ion channels, and signaling molecules to the actin cytoskeleton. It contains multiple domains, including SH3, ankyrin repeats, and PDZ domains, which enable interactions with proteins such as PSD-95, NMDA receptors, and cortactin, facilitating synaptic organization and signal transduction. SHANK1 plays a critical role in synaptic stability, plasticity, and neuronal communication, contributing to processes like learning, memory, and behavior. It is highly expressed in the brain, particularly in regions associated with cognition. Mutations or deletions of SHANK1 have been implicated in neurodevelopmental disorders such as autism spectrum disorders (ASD), where impaired synaptic signaling disrupts neural connectivity. Knockout models show altered synaptic morphology, reduced excitatory synaptic transmission, and behavioral deficits, highlighting its essential role in maintaining synaptic function and brain connectivity.
Características del producto
category
ELISA Kits
immunogen target
SH3 And Multiple Ankyrin Repeat Domains 1 (SHANK1)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
SSTRIP,SPANK-1,synamon
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
SHANK1
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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