SH3 And Multiple Ankyrin Repeat Domains 2 (SHANK2) Antibody
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Description
SHANK2 Antibody is a Rabbit Polyclonal against SHANK2.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | SH3 And Multiple Ankyrin Repeat Domains 2 (SHANK2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/200 - 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UPX8 |
| Gene ID | 22941 |
| Alias | SHANK2, AUTS17, CORTBP1, CTTNBP1, ProSAP1, SHANK, SPANK-3, SH3 and multiple ankyrin repeat domains 2 |
| Background | Antibody anti-SHANK2 |
| Status | RUO |
Descripción
SHANK2 is a postsynaptic scaffold protein that organizes signaling complexes at excitatory synapses by interacting with receptors, signaling proteins, and the cytoskeleton. It contains SH3, ankyrin repeats, and PDZ domains, allowing it to connect NMDA receptors, AMPA receptors, and metabotropic glutamate receptors (mGluRs) to actin-regulatory proteins, coordinating synaptic structure and signaling. SHANK2 is widely expressed in the brain, especially in the hippocampus and cerebellum, where it regulates synaptic plasticity and neuronal excitability. Mutations in SHANK2 are linked to autism spectrum disorders (ASD), intellectual disability, and schizophrenia, with disruptions in synaptic signaling leading to impaired cognition and behavior. Functional studies reveal synaptic deficits, altered glutamatergic transmission, and abnormal neuronal morphology in SHANK2-deficient models, emphasizing its importance in synapse formation, plasticity, and neural development.
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SH3 And Multiple Ankyrin Repeat Domains 2 (SHANK2) Antibody
This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined. [provided by RefSeq].
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SH3 And Multiple Ankyrin Repeat Domains 2 (SHANK2) Antibody
SHANK2 Antibody is a Rabbit Polyclonal against SHANK2.
Ver ProductoSH3 And Multiple Ankyrin Repeat Domains 2 (SHANK2) Antibody
SHANK2 Antibody is a Rabbit Polyclonal against SHANK2.
Ver Producto