Mouse SH3 and multiple ankyrin repeat domains protein 2 (SHANK2) ELISA Kit
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Description
Mouse SH3 and multiple ankyrin repeat domains protein 2 (SHANK2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse SH3 and multiple ankyrin repeat domains protein 2 concentrations in tissue homogenates, cell lysates and other biological fluids.
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Product specifications
| Category | ELISA Kits |
| Immunogen Target | SH3 and multiple ankyrin repeat domains protein 2 (SHANK2) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q80Z38 |
| Gene ID | 210274 |
| Alias | SHANK2, AUTS17, CORTBP1, CTTNBP1, ProSAP1, SHANK, SPANK-3, SH3 and multiple ankyrin repeat domains 2 |
| Background | Elisa kits for SHANK2 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
SHANK2 is a postsynaptic scaffold protein that organizes signaling complexes at excitatory synapses by interacting with receptors, signaling proteins, and the cytoskeleton. It contains SH3, ankyrin repeats, and PDZ domains, allowing it to connect NMDA receptors, AMPA receptors, and metabotropic glutamate receptors (mGluRs) to actin-regulatory proteins, coordinating synaptic structure and signaling. SHANK2 is widely expressed in the brain, especially in the hippocampus and cerebellum, where it regulates synaptic plasticity and neuronal excitability. Mutations in SHANK2 are linked to autism spectrum disorders (ASD), intellectual disability, and schizophrenia, with disruptions in synaptic signaling leading to impaired cognition and behavior. Functional studies reveal synaptic deficits, altered glutamatergic transmission, and abnormal neuronal morphology in SHANK2-deficient models, emphasizing its importance in synapse formation, plasticity, and neural development.
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