Human Putative uncharacterized protein SHANK2-AS3 (SHANK2-AS3) ELISA Kit

Este producto es parte de SHANK - SH3 and multiple ankyrin repeat domains 1
Human Putative uncharacterized protein SHANK2-AS3 (SHANK2-AS3) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for SHANK2

proveedor

Abbexa

reference

abx545705

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human Putative uncharacterized protein SHANK2-AS3 (SHANK2-AS3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Putative uncharacterized protein SHANK2-AS3 (SHANK2-AS3) concentrations in serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.


Background

SHANK2 is a postsynaptic scaffold protein that organizes signaling complexes at excitatory synapses by interacting with receptors, signaling proteins, and the cytoskeleton. It contains SH3, ankyrin repeats, and PDZ domains, allowing it to connect NMDA receptors, AMPA receptors, and metabotropic glutamate receptors (mGluRs) to actin-regulatory proteins, coordinating synaptic structure and signaling. SHANK2 is widely expressed in the brain, especially in the hippocampus and cerebellum, where it regulates synaptic plasticity and neuronal excitability. Mutations in SHANK2 are linked to autism spectrum disorders (ASD), intellectual disability, and schizophrenia, with disruptions in synaptic signaling leading to impaired cognition and behavior. Functional studies reveal synaptic deficits, altered glutamatergic transmission, and abnormal neuronal morphology in SHANK2-deficient models, emphasizing its importance in synapse formation, plasticity, and neural development.

Características del producto

category

ELISA Kits


immunogen target

Putative uncharacterized protein SHANK2-AS3 (SHANK2-AS3)


reactivity

Human


test range

0.156 ng/ml - 10 ng/ml


sensitivity

< 0.07 ng/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.


size 1

96 tests


alias

SHANK2, AUTS17, CORTBP1, CTTNBP1, ProSAP1, SHANK, SPANK-3, SH3 and multiple ankyrin repeat domains 2


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

SHANK2


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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