Sh3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) Antibody
637€ (100 µl)
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Name
Sh3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx115512
Tested Applications
ELISA, WB
Description
Sh3 And Multiple Ankyrin Repeat Domains 1 Antibody is a Rabbit Polyclonal antibody against Sh3 And Multiple Ankyrin Repeat Domains 1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Sh3 And Multiple Ankyrin Repeat Domains 1 (SHANK1) Immunogen: Human SHANK1. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | 0.1M NaHCO3,0.1M Glycine, 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y566 |
| Gene ID | 50944 |
| NCBI Accession | NP_057232.2, NM_016148.3 |
| OMIM | 604999 |
| Alias | SSTRIP,SPANK-1,synamon |
| Background | Antibody anti-SHANK1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
SHANK1 is a scaffold protein in the postsynaptic density (PSD) of excitatory synapses that links receptors, ion channels, and signaling molecules to the actin cytoskeleton. It contains multiple domains, including SH3, ankyrin repeats, and PDZ domains, which enable interactions with proteins such as PSD-95, NMDA receptors, and cortactin, facilitating synaptic organization and signal transduction. SHANK1 plays a critical role in synaptic stability, plasticity, and neuronal communication, contributing to processes like learning, memory, and behavior. It is highly expressed in the brain, particularly in regions associated with cognition. Mutations or deletions of SHANK1 have been implicated in neurodevelopmental disorders such as autism spectrum disorders (ASD), where impaired synaptic signaling disrupts neural connectivity. Knockout models show altered synaptic morphology, reduced excitatory synaptic transmission, and behavioral deficits, highlighting its essential role in maintaining synaptic function and brain connectivity.
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