Human SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) ELISA Kit

Este producto es parte de SHANK - SH3 and multiple ankyrin repeat domains 1
Human SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for SHANK3

proveedor

Abbexa

reference

abx545702

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human SH3 and multiple ankyrin repeat domains protein 3 (SHANK3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human SH3 and multiple ankyrin repeat domains protein 3 (SHANK3) concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

SHANK3 is a critical postsynaptic scaffold protein that assembles and stabilizes signaling complexes at excitatory synapses by connecting neurotransmitter receptors, ion channels, and actin cytoskeleton regulators. It contains SH3, ankyrin repeats, SAM, and PDZ domains, allowing it to interact with NMDA receptors, AMPA receptors, and mGluRs, facilitating synaptic signaling and plasticity. SHANK3 is highly expressed in the brain, particularly in the striatum, cortex, and hippocampus, where it regulates synaptic development, transmission, and plasticity. Mutations or deletions of SHANK3 are strongly associated with Phelan-McDermid syndrome, autism spectrum disorders (ASD), and intellectual disability, characterized by impaired synaptic function, neural connectivity, and behavior. SHANK3-deficient models show severe synaptic defects, altered dendritic spine morphology, and abnormal behavior, underscoring its fundamental role in excitatory synapse maintenance, neuronal communication, and cognitive processes.

Características del producto

category

ELISA Kits


immunogen target

SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3)


reactivity

Human


test range

0.156 ng/ml - 10 ng/ml


sensitivity

< 0.1 ng/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

KIAA1650,PROSAP2,PSAP2,Proline-rich synapse-associated protein 2,ProSAP2,SPANK-2


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

SHANK3


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


Quizá le pueda interesar

Human SHANK3(SH3 and multiple ankyrin repeat domains protein 3)ELISA Kit

Human  SHANK3(SH3 and multiple ankyrin repeat domains protein 3)ELISA Kit

proveedor

FineTest

reference

EH4462

reactivity

human

status

RUO

Precio a consultar

Ver más

SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) Antibody (ATTO390)

SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) Antibody (ATTO390)

proveedor

Abbexa

reference

abx440138

Tested Applications

WB, IHC, IF/ICC, IP, AM

reactivity

Human, Mouse, Rat

status

RUO

clonality

Monoclonal

SHANK3 Antibody is a Mouse Monoclonal against SHANK3.

650€ (100 µg)

Ver más

SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) Antibody (ATTO390)

SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) Antibody (ATTO390)

proveedor

Abbexa

reference

abx440218

Tested Applications

WB, IHC, IF/ICC

reactivity

Human, Mouse, Rat

status

RUO

clonality

Monoclonal

SHANK1/SHANK3 Antibody is a Mouse Monoclonal conjugated to ATTO 390 against SHANK3.

650€ (100 µg)

Ver más