Rat SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for SHANK3
proveedor
Abbexareference
abx545704Tested Applications
ELISAreactivity
Ratstatus
RUOclonality
Descripción
Rat SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat SH3 and multiple ankyrin repeat domains protein 3 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
SHANK3 is a critical postsynaptic scaffold protein that assembles and stabilizes signaling complexes at excitatory synapses by connecting neurotransmitter receptors, ion channels, and actin cytoskeleton regulators. It contains SH3, ankyrin repeats, SAM, and PDZ domains, allowing it to interact with NMDA receptors, AMPA receptors, and mGluRs, facilitating synaptic signaling and plasticity. SHANK3 is highly expressed in the brain, particularly in the striatum, cortex, and hippocampus, where it regulates synaptic development, transmission, and plasticity. Mutations or deletions of SHANK3 are strongly associated with Phelan-McDermid syndrome, autism spectrum disorders (ASD), and intellectual disability, characterized by impaired synaptic function, neural connectivity, and behavior. SHANK3-deficient models show severe synaptic defects, altered dendritic spine morphology, and abnormal behavior, underscoring its fundamental role in excitatory synapse maintenance, neuronal communication, and cognitive processes.
Características del producto
category
ELISA Kits
immunogen target
SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3)
reactivity
Rat
test range
0.312 ng/ml - 20 ng/ml
sensitivity
< 0.16 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
KIAA1650,PROSAP2,PSAP2,Proline-rich synapse-associated protein 2,ProSAP2,SPANK-2
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
SHANK3
dry ice
No
uniprot id
NCBI accession
NP_067708.1
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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