Rat SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) ELISA Kit
715€ (96 tests)
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935106861
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name
Rat SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx545704
tested applications
ELISA
Description
Rat SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat SH3 and multiple ankyrin repeat domains protein 3 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | < 0.16 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9JLU4 |
| Gene ID | 59312 |
| NCBI Accession | NP_067708.1 |
| Alias | KIAA1650,PROSAP2,PSAP2,Proline-rich synapse-associated protein 2,ProSAP2,SPANK-2 |
| Background | Elisa kits for SHANK3 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
SHANK3 is a critical postsynaptic scaffold protein that assembles and stabilizes signaling complexes at excitatory synapses by connecting neurotransmitter receptors, ion channels, and actin cytoskeleton regulators. It contains SH3, ankyrin repeats, SAM, and PDZ domains, allowing it to interact with NMDA receptors, AMPA receptors, and mGluRs, facilitating synaptic signaling and plasticity. SHANK3 is highly expressed in the brain, particularly in the striatum, cortex, and hippocampus, where it regulates synaptic development, transmission, and plasticity. Mutations or deletions of SHANK3 are strongly associated with Phelan-McDermid syndrome, autism spectrum disorders (ASD), and intellectual disability, characterized by impaired synaptic function, neural connectivity, and behavior. SHANK3-deficient models show severe synaptic defects, altered dendritic spine morphology, and abnormal behavior, underscoring its fundamental role in excitatory synapse maintenance, neuronal communication, and cognitive processes.
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