anti- SHANK1 antibody
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name
anti- SHANK1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab07837
tested applications
ELISA, WB
Description
Seems to be an adapter protein in the postsynaptic density(PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | SH3 and multiple ankyrin repeat domains 1 |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 250-300 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9Y566 |
| Gene ID | 50944 |
| Alias | SSTRIP,SPANK-1,synamon |
| Background | Antibody anti-SHANK1 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
SHANK1 is a scaffold protein in the postsynaptic density (PSD) of excitatory synapses that links receptors, ion channels, and signaling molecules to the actin cytoskeleton. It contains multiple domains, including SH3, ankyrin repeats, and PDZ domains, which enable interactions with proteins such as PSD-95, NMDA receptors, and cortactin, facilitating synaptic organization and signal transduction. SHANK1 plays a critical role in synaptic stability, plasticity, and neuronal communication, contributing to processes like learning, memory, and behavior. It is highly expressed in the brain, particularly in regions associated with cognition. Mutations or deletions of SHANK1 have been implicated in neurodevelopmental disorders such as autism spectrum disorders (ASD), where impaired synaptic signaling disrupts neural connectivity. Knockout models show altered synaptic morphology, reduced excitatory synaptic transmission, and behavioral deficits, highlighting its essential role in maintaining synaptic function and brain connectivity.
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