Human SHANK3(SH3 and multiple ankyrin repeat domains protein 3)ELISA Kit

Product specifications

ELISA Kits

human

Colorimetric

Quantitative

Sandwich ELISA, Double Antibody

0.156-10ng/ml

96T

Serum,Plasma,Tissue homogenates,Other biological fluids

Shipped within 10-14 working days.

2-8 °C for 6 months

Q9BYB0

KIAA1650,PROSAP2,PSAP2,Proline-rich synapse-associated protein 2,ProSAP2,SPANK-2

Elisa Kits SHANK3

RUO

SHANK3 is a critical postsynaptic scaffold protein that assembles and stabilizes signaling complexes at excitatory synapses by connecting neurotransmitter receptors, ion channels, and actin cytoskeleton regulators. It contains SH3, ankyrin repeats, SAM, and PDZ domains, allowing it to interact with NMDA receptors, AMPA receptors, and mGluRs, facilitating synaptic signaling and plasticity. SHANK3 is highly expressed in the brain, particularly in the striatum, cortex, and hippocampus, where it regulates synaptic development, transmission, and plasticity. Mutations or deletions of SHANK3 are strongly associated with Phelan-McDermid syndrome, autism spectrum disorders (ASD), and intellectual disability, characterized by impaired synaptic function, neural connectivity, and behavior. SHANK3-deficient models show severe synaptic defects, altered dendritic spine morphology, and abnormal behavior, underscoring its fundamental role in excitatory synapse maintenance, neuronal communication, and cognitive processes.

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